阿加曲班联合依达拉奉治疗急性脑梗死的临床效果

Clinical efficacy of argatroban combined with edaravone in treatment of acute cerebral infarction

目的探讨阿加曲班联合依达拉奉治疗急性脑梗死的临床效果。方法回顾性纳入2019年1月至2020年12月驻马店市中心医院收治的接受药物治疗的急性脑梗死患者96例。根据用药不同分为依达拉奉组(45例)和联合治疗组(51例)。比较两组患者的临床疗效, 治疗前后神经功能缺损情况和日常生活能力、外周血超氧化物歧化酶(SOD)和丙二醛(MDA)水平。结果治疗2周后, 联合治疗组患者临床总有效率高于依达拉奉组(P<0.05)。治疗前两组患者美国国立卫生院神经功能缺损评分(NIHSS评分)和日常生活能力(ADL)评分比较, P>0.05;治疗2周后, 联合治疗组患者NIHSS评分低于依达拉奉组, ADL评分高于依达拉奉组, P<0.05。治疗前两组患者SOD和MDA水平比较, P>0.05;治疗2周后联合治疗组患者SOD水平高于依达拉奉组, MDA水平低于依达拉奉组(P<0.05)。结论阿加曲班联合依达拉奉治疗急性脑梗死具有较好的临床疗效, 联合用药可通过抗自由基、抗凝、改善脑部微循环等机制, 改善脑细胞损伤, 促进脑神经功能的恢复, 提高患者生活能力。

Objective To explore the clinical efficacy of argatroban combined with edaravone in the treatment of acute cerebral infarction.Methods Ninety-six patients with acute cerebral infarction treated with drugs in Zhumadian Central Hospital from January 2019 to December 2020 were included retrospectively.According to different drugs,they were divided into edaravone group(45 cases)and combination therapy group(51 cases).The clinical efficacy,neurological deficits and activities of daily living,Superoxide dismutase(SOD)and malondialdehyde(MDA)levels in peripheral blood before and after treatment were compared between the two groups.Results After two weeks of treatment,the total clinical effective rate of the patients in combination therapy group was higher than that of the patients in edaravone group(P<0.05).Before treatment,National Institute Health of Stroke Scale(NIHSS)score and activities of daily living(ADL)score were compared between the two groups(P>0.05).After two weeks of treatment,the NIHSS score and ADL score in combination therapy group were lower than those in edaravone group,P<0.05.Before treatment,comparison of SOD and MDA levels between the two groups,P>0.05.After two weeks of treatment,the SOD level in the combination therapy group was higher than that in edaravone group,while the MDA level was lower than that in edaravone group(P<0.05).Conclusions Agatraban combined with edaravone has a good clinical effect in the treatment of acute cerebral infarction.Combined medication can improve brain cell injury,promote the recovery of brain nerve function and improve the living ability of patients through anti-free radical,anticoagulation and improvement of brain microcirculation.