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化痰消瘀方与胃复春治疗胃癌癌前病变合并Hp感染的效果比较 被引量:7

Comparison of the effect of huatan xiaoyu recipe and weifuchun on precancerous lesions of gastric cancer with Hp infection
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摘要 目的比较化痰消瘀方与胃复春治疗胃癌癌前病变合并胃幽门螺旋杆菌(Hp)感染的效果。方法抽取2018年2月至2020年2月郑州人民医院收治的胃癌癌前病变合并Hp感染患者96例, 按随机数字表法分为观察组和对照组, 每组48例。两组均接受常规标准四联Hp根治疗法, 对照组在此基础上给予胃复春片口服, 观察组则给予化痰消瘀方随症加减治疗, 疗程共计180 d;观察两组患者的治疗有效率, 比较治疗前后中医主症状评分、胃黏膜病理积分, 统计Hp清除率及治疗过程中不良反应发生情况。结果观察组治疗有效率和Hp清除率高于对照组(P<0.05);治疗后两组中医主症状胃脘疼痛、胁肋胀闷、嗳气呃逆、烧心反酸、纳滞少食等评分及胃黏膜萎缩、肠化生、不典型增生评分均降低, 且观察组上述评分变化更显著(P<0.05);两组无不良反应发生。结论化痰消瘀方治疗胃癌癌前病变合并Hp感染的临床疗效优于胃复春, 可改善中医主症状及胃黏膜病变程度, 且无明显不良反应。 Objective To compare the effect of huatan xiaoyu recipe and weifuchun on precancerous lesions of gastric cancer(PLGC)with helicobacter pylori(Hp)infection.Methods A total of 96 patients with PLGC and Hp infection in Zhengzhou People’s Hospital from February 2018 to February 2020 were enrolled and divided into observation group and control group,they were randomly divided into observation group and control group,with 48 cases in each group.The two groups were treated with routine and standard quadruple therapy for Hp eradication.On this basis,the control group was given weifuchun,while the observation group was given huatan xiaoyu recipe for 180 days.The response rates of treatment in both groups were observed.The changes in scores of main TCM symptoms and gastric mucosal pathology were compared.Hp clearance rate and occurrence of adverse reactions during treatment were statistically analyzed.Results The response rate of treatment and Hp clearance rate in observation group were higher than those in control group(P<0.05).After treatment,the scores of TCM main symptoms(epigastric pain,lateral thorax swelling,belching and hiccups,heartburn and acid reflux,anorexia),gastric mucosa atrophy,intestinal metaplasia and atypical hyperplasia in both groups were significantly decreased,which were significantly lower in observation group than those in control group(P<0.05).Conclusions The clinical curative effect of huatan xiaoyu recipe is better than that of weifuchun on PLGC,which can significantly improve main TCM symptoms and gastric mucosal lesions,without significant adverse reactions.
作者 朱彦生 秦向阳 Zhu Yansheng;Qin Xiangyang(Department of Integrated Traditional Chinese and Western Medicine,Zhengzhou People’s Hospital,Zhengzhou 450000,China)
出处 《中国实用医刊》 2021年第20期117-120,共4页 Chinese Journal of Practical Medicine
关键词 胃癌 癌前病变 化痰消瘀方 胃复春 Gastric cancer Precancerous lesions Huatan xiaoyu recipe Weifuchun
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