摘要
近年来,肿瘤免疫治疗领域发展迅速,围绕肿瘤微环境中的免疫抑制、表观遗传修饰和能量代谢等多种机制涌现出诸多新靶点。这些新兴靶点为药物临床前研究及临床应用提供了更多参考,有望改善现有肿瘤免疫疗法的不足,具有潜在的应用前景及临床价值。该文对当前肿瘤免疫新兴靶点的特性及其药物开发情况进行综述。
In recent years, the field of cancer immunotherapy has developed rapidly and many novel targets have emerged for immunosuppression in the tumor microenvironment, epigenetic modification, energy metabolism and other mechanisms. These emerging targets provide more references for preclinical research and clinical application of medicines, and are expected to improve the deficiency of current cancer immunotherapy, and have potential application prospects and clinical value. In this paper, the characteristics and drug development status of emerging cancer immunotherapy targets are reviewed.
作者
毛艳艳
刘丽丽
黄瑶庆
MAO Yan-Yan;LIU Li-Li;HUANG Yao-Qing(Information Center,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China)
出处
《生命科学》
CSCD
北大核心
2021年第10期1225-1230,共6页
Chinese Bulletin of Life Sciences
基金
中国科学院A类战略性先导科技专项(XDA-12050201)。
关键词
抗肿瘤
肿瘤免疫治疗
靶点
免疫检查点
肿瘤微环境
anti-tumor
cancer immunotherapy
target
immune checkpoints
tumor microenvironment