摘要
基质金属蛋白酶(matrix metalloproteinases,MMPs)是一类Zn;、Ca;依赖性蛋白水解酶,在动物组织中已分离鉴定出MMPs家族的28种亚型。国内外对明胶类酶MMP-2和MMP-9在动物正常生理条件下的骨骼肌生长发育、病理条件下的骨骼肌修复与再生等方面的研究较多,并且近年来明胶类酶MMPs在畜禽骨骼肌生长和肉质改良中的作用也逐渐成为MMPs研究的热点。该文在总结动物骨骼肌中明胶类酶MMPs研究进展的基础上,对目前MMP-2和MMP-9在骨骼肌组织研究中存在的局限性进行了初步分析和探讨,以期为MMPs的进一步研究和应用提供参考。
Matrix metalloproteinases(MMPs)are a type of Zn;-and Ca;-dependent proteolytic enzymes.In animal tissues,28 subtypes of MMPs family have been isolated and identified in animal tissues.There are many domestic and foreign researches on the skeletal muscle growth and development of gelatinase MMP-2 and MMP-9 under normal physiological conditions in animals,and the repair and regeneration of skeletal muscle under pathological conditions.In recent years,the role of gelatinase MMPs in livestock and poultry skeletal muscle growth and meat quality improvement is gradually becoming a research hotspot.Based on the summary of the research progress of gelatinase MMPs in animal skeletal muscles,we analyze and discuss the current limitations of MMP-2 and MMP-9 in skeletal muscle tissue research,with a view to provide reference for further research and application of MMPs.
作者
欧阳谭亮
武志娟
钟金城
OUYANG Tan-Liang;WU Zhi-Juan;ZHONG Jin-Cheng(Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization,Sichuan Province and Ministry of Education,Southwest Minzu University,Chengdu 610041,China;Institute of Tibetan Plateau Research,Southwest Minzu University,Chengdu 610041,China)
出处
《生命科学》
CSCD
北大核心
2021年第10期1286-1295,共10页
Chinese Bulletin of Life Sciences
基金
西南民族大学研究生创新型科研项目(CX2021SZ20)
省部共建青稞和牦牛种质资源与遗传改良国家重点实验室开放基金项目(XZNKY-2021-C-014-K08)
财政部和农业农村部国家现代农业产业技术体系项目(CARS-37)。
关键词
基质金属蛋白酶
骨骼肌
肌细胞
畜禽
matrix metalloproteinases
skeletal muscle
muscle cells
livestock
