血清中IL-7、PGLYRP-1、SOST的表达水平对类风湿性关节炎的诊断价值

The diagnostic value of serum IL-7, PGLYRP 1, SOST expression levels in rheumatoid arthritis

目的探讨血清中白介素7(interleukin 7,IL-7)、肽聚糖识别蛋白1(peptidoglycan recognition protein 1,PGLYRP-1)、硬骨素(sclerostin,SOST)的表达水平对类风湿性关节炎的诊断价值。方法纳入2019年5月至2021年5月达州市中心医院收治的类风湿性关节炎患者82例为类风湿组、非类风湿性关节炎患者82例为非类风湿组、健康体检者82例为对照组。检测3组受试人员血清中IL-7, PGLYRP-1, SOST的表达量;用受试者工作特征曲线(receiver operating characteristic curve,ROC)的曲线下面积(area under curve,AUC)评估IL-7, PGLYRP-1, SOST检测在类风湿性关节炎中的诊断意义。结果类风湿组患者血清中的IL-7和SOST均低于非类风湿组和对照组(P<0.05),类风湿组患者血清中的PGLYRP-1高于非类风湿组患者和对照组(P<0.05)。IL-7、PGLYRP-1、SOST单向诊断类风湿性组患者与非类风湿组患者的灵敏度分别为90%、86%、98%,特异度分别为72%、89%、61%。血清中IL-7,PGLYRP-1, SOST联合对类风湿性关节炎的诊断的的灵敏度为91.46%,特异度为75.61%,准确度为80.89%。此外,非条件logistic逐步回归分析结果显示血清中IL-7, PGLYRP-1, SOST的表达水平均是患类风湿关节炎的重要危险因素。结论血清中IL-7、PGLYRP-1、SOST的表达水平可作为诊断类风湿性关节炎的潜在指标。

Objective To investigate the diagnostic value of serum IL-7, PGLYRP-1 and SOST in rheumatoid arthritis. Methods A total of 82 rheumatoid arthritis patients admitted to our hospital from May 2019 to May 2021 were included in the rheumatoid group, 82 non-rheumatoid arthritis patients were included in the non-rheumatoid group,and 82 healthy individuals were included in the control group. The expression levels of IL-7, PGLYRP-1 and SOST in serum of 3 groups were detected. area under curve(AUC)of receiver operating characteristic curve(ROC) was used to analyze the diagnostic significance of IL-7, PGLYRP 1 and SOST in rheumatoid arthritis. Results The levels of IL-7 and SOST in serum of rheumatoid arthritis patients were lower than those of non-rheumatoid arthritis patients and healthy subjects(P<0.05), and the levels of PGLYRP-1 in serum of rheumatoid arthritis patients were higher than those of non-rheumatoid arthritis patients and healthy subjects(P<0.05). The sensitivity of IL-7, PGLYRP 1 and SOST for one-way diagnosis of rheumatoid arthritis patients and non-rheumatoid arthritis patients were 90%, 86%, 98%, and the specificity was 72%, 89%, 61%, respectively. The sensitivity, specificity and accuracy of serum IL-7, PGLYRP 1 and SOST combined in the diagnosis of rheumatoid arthritis were 91.46%, 75.61% and 80.89% respectively. In addition, the results of unconditional logistic stepwise regression analysis showed that the expression levels of IL-7, PGLYRP-1 and SOST in serum were important risk factors for rheumatoid arthritis. Conclusion The expression levels of IL-7, PGLYRP 1 and SOST in serum can be used as potential indicators for the diagnosis of rheumatoid arthritis.