线粒体DNA介导的细胞焦亡与脓毒症

Mitochondrial DNA-mediated pyroptosis and sepsis

脓毒症是宿主对感染反应失调引起的严重危及生命的器官功能障碍性疾病,是重症监护病房常见的死亡原因。焦亡是由含半胱氨酸的天冬氨酸蛋白水解酶介导的一种坏死和炎性程序性细胞死亡,其机制分为典型炎性小体激活和非典型炎性小体激活,caspase-1/11及消皮素D是焦亡发挥作用的关键底物。线粒体DNA作为一种损伤相关分子模式介导细胞焦亡,与脓毒症严重程度相关。本文就线粒体DNA介导的细胞焦亡与脓毒症的关系进展作一综述。

Sepsis is a serious life-threatening organ dysfunction disease caused by the host′s unbalanced response to infection,and it′s a common cause of death in intensive care units.Pyroptosis is a kind of necrosis and inflammatory programmed cell death mediated by caspase.Its mechanism can be divided into typical inflammasome activation and atypical inflammasome activation.Caspase-1/11 and Gasdermin-D are the key substrates for pyroptosis.Mitochondrial DNA(mtDNA)as a damage-associated molecular pattern mediates pyroptosis and is associated with severity of sepsis.This review summarized the progress on the relationship between mtDNA-mediated pyroptosis and sepsis.