高迁移率族蛋白1在川崎病冠状动脉病变中的作用机制

The mechanism of high mobility group box 1 in coronary artery lesions of Kawasaki disease

川崎病是一种常见的儿童急性发热性血管炎性疾病, 病因与发病机制未明。最严重的后遗症是冠状动脉病变, 而血管内皮细胞损伤可能是冠状动脉病变发生的关键机制。研究发现在川崎病急性期, 高迁移率族蛋白1(high mobility group box 1, HMGB1)血清水平升高, 尤其是在合并冠状动脉病变的患儿中更高, 且发现HMGB1基因与川崎病患儿冠状动脉病变有关。HMGB1是一种与炎症反应有关的非组蛋白DNA结合蛋白, 通过HMGB1/RAGE通路在促进川崎病冠状动脉内皮细胞凋亡方面起重要作用。现就HMGB1在川崎病冠状动脉病变中的作用机制进行综述。

Kawasaki disease(KD)is a common acute febrile vasculitis in children,but the etiology and pathogenesis of KD are unknown.The most serious complication is coronary artery lesions.The damage of vascular endothelial cell may be the key mechanism of coronary artery lesions in KD.It is found that serum levels of high mobility group box 1(HMGB1)increase in the acute phase of KD,especially in children with coronary artery lesions,and that the gene of HMGB1 is associated with coronary artery lesions in Korean children with KD.HMGB1 is a non-histone DNA binding protein related to inflammation,which plays an important role in promoting the apoptosis of coronary artery endothelial cells in KD.The article reviews the mechanism of HMGB1 in coronary artery lesions of KD.