阿胶强骨口服液联合骨化三醇治疗老年骨质疏松的临床研究

Clinical study of Ejiao Qianggu Oral Liquid combined with calcitriol in treatment of senile osteoporosis

目的探讨阿胶强骨口服液联合骨化三醇胶丸治疗老年骨质疏松的临床疗效。方法选取2019年3月—2021年3月在安康市人民医院就诊治疗的128例老年骨质疏松患者,根据随机数字法将128例老年骨质疏松患者分为对照组(n=64)和治疗组(n=64)。对照组口服骨化三醇胶丸,1粒/次,2次/d。治疗组在对照组的基础上口服阿胶强骨口服液,10 mL/次,3次/d。两组患者均连续服用药物3个月。观察两组的临床疗效,比较两组临床症状好转时间、骨代谢指标和骨密度的变化。结果治疗后,治疗组患者总有效率是98.44%,显著高于对照组的84.38%(P<0.05)。治疗组患者腰酸背痛好转时间、骨骼疼痛好转时间、下肢无力好转时间、肌肉痉挛好转时间均显著短于对照组(P<0.05)。治疗后,两组Ⅰ型胶原羧基端交联肽(CTX)、血清Ⅰ型胶原氨基端前肽(P1NP)均显著降低,但25-羟基维生素D[25(OH)D]、骨钙素(BGP)升高(P<0.05);治疗后,治疗组骨代谢指标改善优于对照组(P<0.05)。治疗后,两组患者股骨颈骨骨密度、腰椎骨骨密度、股骨大转子骨密度均较治疗前显著升高(P<0.05);治疗后,治疗组骨密度改善优于对照组(P<0.05)。结论阿胶强骨口服液联合骨化三醇胶丸治疗老年骨质疏松临床疗效显著,能有效改善骨密度,增强骨代谢功能,值得临床推广应用。

Objective To investigate the curative effect of Ejiao Qianggu Oral Liquid combined with Calcitriol Capsules in treatment of senile osteoporosis. Methods A total of 128 elderly patients with osteoporosis treated in Ankang People’s Hospital from March 2019 to March 2021 were selected. According to the random number method, 128 elderly patients with osteoporosis were divided into control group(n=64) and treatment group(n=64). Patients in the control group were po administered with Calcitriol Soft Capsules, 1 grain/time, twice daily. Patients in the treatment group were po administered with Ejiao Qianggu Oral Liquid on the basis of the control group, 10 mL/time, three times daily. Both groups were given drugs for 3 months. The clinical efficacy of the two groups were observed,and the improvement time of clinical symptoms, bone metabolism index, and bone mineral density were compared between the two groups. Results After treatment, the total effective rate in treatment group was 98.44%, significantly higher than that in control group(84.38%)(P < 0.05). The improvement time of back pain, bone pain, lower limb weakness, and muscle spasm in treatment group was significantly shorter than that in control group(P < 0.05). After treatment, CTX and P1 NP were significantly decreased, but 25(OH)D and BGP were increased in both groups(P < 0.05). After treatment, the improvement of bone metabolism index in treatment group was better than that in control group(P < 0.05). After treatment, bone mineral density of femoral neck, lumbar vertebra and greater trochanter in two groups were significantly increased compared with before treatment(P < 0.05). After treatment, BMD in the treatment group was better than that in the control group(P < 0.05). Conclusion Ejiao Qianggu Oral Liquid combined with calcitriol has significant clinical effect in treatment of senile osteoporosis, and can effectively improve bone mineral density and enhance bone metabolism, which is worthy of clinical application.