知柏地黄丸联合右归胶囊治疗肾虚型少弱精子症的疗效观察

Zhibai Dihuang Pills combined with Yougui Capsules in treatment of oligoasthenospermia of kidney deficiency type

目的观察知柏地黄丸联合右归胶囊治疗肾虚型少弱精子症的临床疗效。方法选取2017年3月—2020年8月天津市宁河区医院收治的100例少弱精子症患者,根据信封抽签法分为对照组(50例)和治疗组(50例)。对照组早晚餐后口服右归胶囊,4粒/次,3次/d。治疗组在对照组的基础上口服知柏地黄丸,8丸/次,3次/d。两组均治疗3个月。观察两组患者临床疗效,比较治疗前后两组患者向前运动精子百分率、精子密度、活动精子百分率、中医证候积分及性激素指标睾酮(T)、雌二醇(E;)和黄体生成素(LH)水平。结果治疗后,治疗组总有效率明显高于对照组(90.00%vs 70.00%,P<0.05)。治疗后,两组前向运动精子百分率、精子密度、活动精子百分率明显升高(P<0.05),且治疗组高于对照组(P<0.05)。治疗后,两组患者中医症候积分明显降低(P<0.05),且治疗组明显低于对照组(P<0.05)。治疗后,两组T、LH水平明显高于治疗前,而E;明显低于治疗前(P<0.05),且治疗组T、LH和E;水平明显好于对照组(P<0.05)。结论知柏地黄丸联合右归胶囊治疗肾虚型少弱精子症,可促进临床症状改善,有效调节性激素水平、精子质量。

Objective To observe the clinical effect of Zhibai Dihuang Pills combined with Yougui Capsules in treatment of oligoasthenospermia of kidney deficiency type. Methods Patients(100 cases) with oligoasthenospermia of kidney deficiency type in Tianjin Ninghe Hospital from March 2017 to August 2020 were divided into control(50 cases) and treatment(50 cases) groups according to the envelope lottery. Patients in the control group were po administered with Yougui Capsules after breakfast and dinner, 4 grains/time,three times daily. Patients in the treatment group were po administered with Zhibai Dihuang Pills, 8 pills/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical evaluation was evaluated, the improvement time of clinical symptoms,the PR sperm percentage, sperm density, motile sperm percentage, TCM syndrome scores, the levels of sex hormone indexes T, LH and E;in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was significantly higher than that of the control group(90.00% vs 70.00%, P < 0.05). After treatment, the percentage of forward motile sperm,sperm density, and the percentage of motile sperm were significantly increased in two groups(P < 0.05), and which in the treatment group were higher than those in the control group(P < 0.05). After treatment, the symptom score in two groups were significantly decreased(P <0.05), and which in the treatment group was significantly lower than that of the control group(P < 0.05). After treatment, the levels of T and LH in two groups were significantly higher than those before treatment, while the levels of E;were significantly lower(P < 0.05), and the levels of T, LH, and E;in the treatment group were significantly better than those in the control group(P < 0.05). Conclusion Zhibai Dihuang Pills combined with Yougui Capsules in treatment of oligoasthenospermia of kidney deficiency type can promote the improvement of clinical symptoms and effectively regulate the level of sex hormones and sperm quality.