牙痛停滴丸联合替硝唑治疗智齿冠周炎的临床研究

Clinical study on Yatongting Dripping Pills combined with tinidazole in treatment of wisdom teeth pericoronitis

目的探讨牙痛停滴丸联合替硝唑治疗智齿冠周炎的临床研究。方法选取2019年3月—2021年3月在天津市职业病防治院诊治的92例冠周炎患者,随机分为对照组(46例)和治疗组(46例)。对照组含漱替硝唑含漱液,2 mL混匀到50 mL温开水中,含嗽1 min后吐弃,3次/d。治疗组患者在对照组的基础上于患处口含牙痛停滴丸,2丸/次,3次/d。两组患者连续用药7 d。观察两组患者临床疗效,比较治疗前后两组患者临床症状好转时间,牙周菌斑指数评分(PLI)、出血指数评分(BI)和牙龈指数评分(GI)评分,血清炎性因子白细胞介素-1β(IL-1β)、肿瘤坏死因子α(TNF-α)、降钙素原(PCT)和C反应蛋白(CRP)水平及不良反应情况。结果治疗后,治疗组患者总有效率明显高于对照组(97.82%vs 80.43%,P<0.05);治疗后,治疗组患者临床症状好转时间明显早于对照组(P<0.05);治疗后,两组患者牙周PLI、BI、GI评分比治疗前均明显下降(P<0.05),且治疗组明显低于对照组(P<0.05)。治疗后,两组患者血清炎性因子IL-1β、TNF-α、PCT、CRP水平均明显降低(P<0.05);且治疗组明显低于对照组(P<0.05)。治疗组不良反应总发生率明显低于对照组(6.52%vs15.22%,P<0.05)。结论牙痛停滴丸联合浓替硝唑含漱液治疗冠周炎患者临床效果显著,有效降低牙周炎性反应,且药物不良反应发生率较低。

Objective To investigate the curative effect of Yatongting Dripping Pills combined with tinidazole in treatment of wisdom teeth pericoronitis. Methods Patients(92 cases) with wisdom teeth pericoronitis in Tianjin Occupational Disease Precaution and Therapeutic Hospital from March 2019 to March 2021 were randomly divided into control(46 cases) and treatment(46 cases) groups.Patients in the control group were gargle administered with Concentrated Tinidazole Gargles, 2 mL added into 50 mL warm water, spat out after 1 minute, three times daily. Patients in the treatment group were administered with Yatongting Dripping Pills in the affected area, 2 pills/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical evaluation was evaluated,the improvement time of clinical symptoms, the scores of periodontal PLI, BI, and GI, the levels of IL-1β, TNF-α, PCT, and CRP, and adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was significantly higher than that of the control group(97.82% vs 80.43%, P < 0.05). After treatment, the improvement time of clinical symptoms in the treatment group was significantly earlier than that in the control group(P < 0.05). After treatment, the scores of periodontal PLI, BI, and GI in two groups were significantly lower than those before treatment(P < 0.05), and which in the treatment group were significantly lower than those in the control group(P < 0.05). After treatment, the levels of inflammatory factors IL-1β, TNF-α, PCT, and CRP in two groups were significantly decreased(P < 0.05), and which in the treatment group were significantly lower than those in the control group(P < 0.05). The total incidence of adverse reactions in the treatment group was significantly lower than that in the control group(6.52% vs 15.22%, P < 0.05). Conclusion The clinical effect of Yatongting Dripping Pills combined with tinidazole in treatment of wisdom teeth pericoronitis is remarkable, the periodontal inflammatory reaction is effectively reduced, and the incidence of adverse drug reactions is low.