3型天然淋巴细胞调节炎症性肠病的研究进展

Research progress of group 3 innate lymphoid cells in inflammatory bowel disease

炎症性肠病(inflammatory bowel disease,IBD)是一类病因不明的肠道免疫系统疾病,包括克罗恩病和溃疡性结肠炎。3型天然淋巴细胞(group 3 innate lymphoid cell,ILC3)是天然淋巴细胞中的一种,其主要通过分泌IL-22、IL-17和GM-CSF等细胞因子来调控胃肠道的黏膜免疫。ILC3参与了IBD的进展和加重。该文综述了ILC3的分化发育过程以及ILC3如何调节肠道稳态,探讨了ILC3与IBD发生、发展的相关性以及在临床的应用,以期为IBD的治疗提供一点思路。

Inflammatory bowel disease(IBD)is a class of intestinal immune diseases with unknown causes,which includes Crohn’s disease and ulcerative colitis.Group 3 innate lymphoid cell(ILC3)is a kind of innate lymphoid cells that regulates gastrointestinal mucosal immunity primarily through the secretion of cytokines such as IL-22,IL-17 and GM-CSF.In recent years,a large number of studies have proved that ILC3 is involved in the progression and aggravation of IBD.In this paper,we summarized the differentiation and development of ILC3,and the intestinal homeostasis regulated by ILC3.Meanwhile,we also discussed the correlation between ILC3 and IBD’s development,and show its clinical application.We hope to provide some ideas for the treatment of IBD.