抗肿瘤靶向药物相关皮肤不良反应临床表现及治疗最新进展

Recent study progress on clinical manifestations and treatments of cutaneous adverse reactions caused by anti-tumor targeted drugs

抗肿瘤靶向药物针对肿瘤特异性靶点,在发挥抗肿瘤的同时对正常的皮肤及附属器也会出现不良反应。这些皮肤不良反应严重影响患者生活质量,甚至会因此而改变或停止靶向治疗,最终影响患者长期生存。出现皮肤不良反应的靶向药物种类较多,且临床表现及治疗各异。因此,正确认识抗肿瘤靶向药物相关皮肤不良反应,积极预防并规范治疗就显得尤为重要。

Anti-tumor targeted drugs target tumor-specific targets, besides their anti-tumor effects, this kind of medicine may also bring about the adverse reactions of normal skin and appendages. These cutaneous adverse reactions seriously affect the quality of life of patients, and even lead to the forced change or abandon of targeted therapy, and ultimately affect the long-term survival of patients. There are many kinds of targeted drugs that can lead to cutaneous adverse reactions, and their clinical manifestations and treatment are different. Therefore, it is particularly important to correctly understand, and adopt actively prevention and standardize treatment of the cutaneous adverse reactions related to anti-tumor targeted drugs.