神经递质调节剂在肠易激综合征治疗中的应用

Use of neuromodulators in the treatment of irritable bowel syndrome

肠易激综合征(irritable bowel syndrome,IBS)是常见的功能性胃肠病,多数患者合并精神心理异常且生活质量严重下降。IBS的确切病因尚不清楚,多认为与胃肠动力异常、内脏高敏感、黏膜免疫异常、肠道菌群失调及肠-脑互动异常有关。传统治疗药物对IBS的疗效并不理想,神经递质调节剂包括三环类抗抑郁药和五羟色胺再摄取抑制剂,不仅能调节痛觉感受、降低内脏高敏感、调节胃肠动力、改善IBS患者症状外,还能治疗患者合并存在的精神心理异常。本文就已发表的相关研究对神经递质调节剂在IBS治疗中的应用进行简要综述。

Irritable bowel syndrome(IBS)is the prevalent functional gastrointestinal disorder.In most patients,it is combined with mental and psychological abnormalities and results in a considerable decline in quality of life.The precise etiology of IBS is still unknown,but it may be related to gastrointestinal motility abnormalities,visceral hypersensitivity,mucosal immunity abnormalities,alteration of intestinal flora and gut-brain axis abnormalities.Traditional drugs have been less effective in treating IBS.The neuromodulators,including tricyclic antidepressants and selective serotonin reuptake inhibitors,can not only moderate pain sensation,reduce visceral hypersensitivity,regulate gastrointestinal motility and improve symptoms,but also treat patients associated with mental and psychological abnormalities.In this paper,the application of neuromodulators in the treatment of IBS is briefly reviewed.