CTRP1血清浓度与患者脓毒症心肌损伤预后的关系

Relationship between CTRP1 Serum Concentration and Prognosis of Patients with Septic Myocardial Injury

目的研究脓毒症患者CTRP1血清水平高低与心肌损伤及预后的相关性。方法本研究收集2018年10月~2021年4月就诊于武汉大学人民医院脓毒症患者176例作为研究对象,分为心肌损伤组与非心肌损伤组,选取体检患者63例作为健康对照。采用ELISA法测定CTRP1浓度,并收集结合其临床资料分析研究健康人群与脓毒症患者CTRP1水平,及CTRP1水平与其预后是否有关。结果脓毒症组CTRP1浓度明显高于健康组[58.84(40.30,100.06)ng/ml vs 39.38(28.98,53.97)ng/ml,P<0.01];非心肌损伤组CTRP1浓度明显高于心肌损伤组[65.08(46.65,117.62)ng/ml vs 52.31(39.87,82.50)ng/ml,P=0.01];斯皮尔曼相关性分析显示,CTRP1与休克、心功能不全、心律失常的呈负相关(相关系数:-0.20、-0.19、-0.15,P<0.05)。结论CTRP1可以保护脓毒症患者引起的心功能损伤,为临床脓毒症心功能不全的治疗提供了新的研究方向。

Objective To study the correlation between serum level of CTRP1 and myocardial injury and prognosis in patients with sepsis.Methods A total of 176 patients with sepsis admitted to People′s Hospital of Wuhan University from October 2018 to April 2021 were enrolled in this study.They were divided into the myocardial injury group and the non-myocardial injury group,and 63 physical examination patients were selected as healthy controls.The concentration of CTRP1 was determined by ELISA method,and the CTRP1 level in healthy people and sepsis patients was analyzed by collecting and combining its clinical data,and whether the CTRP1 level was related to the prognosis.Results The concentration of CTRP1 in sepsis group was significantly higher than that in healthy group[58.84(40.30,100.06)ng/ml vs 39.38(28.98,53.97)ng/ml,P<0.01].The concentration of CTRP1 in the non-myocardial injury group was significantly higher than that in the myocardial injury group[65.08(46.65,117.62)ng/ml vs 52.31(39.87,82.50)ng/ml,P=0.01].Spearman correlation analysis showed that CTRP1 was negatively correlated with shock,cardiac insufficiency and arrhythmia(correlation coefficients:-0.20,-0.19,-0.15,P<0.05).Conclusion CTRP1 can protect the heart function damage caused by sepsis,which provides a new research direction for the treatment of sepsis cardiac insufficiency in the future.