视网膜小胶质细胞与神经炎症在阿尔茨海默病中的研究

Retinal microglial and neuroinflammation associated with Alzheimer's disease

阿尔茨海默病(AD)是老年期痴呆最为常见的一种类型,潜伏期长,至今仍缺乏有效的生物标记进行早期诊断。神经炎症在AD病程的发生发展中扮演重要角色,视网膜与中枢神经系统在胚胎发育和解剖生理上具有同源性,可洞察颅内神经病理变化,因此,视网膜小胶质细胞活化及其介导的神经炎症反应可能为AD的早期诊断提供线索。未来研究可以从控制胶质细胞活化及神经炎症的角度考虑,开发新的AD治疗策略。

Alzheimer's disease(AD)is the most common dementia with a long asymptomatic period.Currently,there is still no efficient biomarker to identify AD at the early stage.Neuroinflammation plays a significant role in the neuropathogenesis progresses of AD.The retina and optic nerve extend from the diencephalon during embryonic development and give an insight into the central nervous system.Therefore,retina microglial activation and microglial-mediated neuroinflammation could be potential biomarkers for early diagnosis of AD.In future,it will be vital in developing novel treatment for AD targeting microglial activation and neuroinflammation.