针对不同人群结核病新疫苗研究进展

Progress in researches on novel tuberculosis vaccine for different populations:a review

结核病是严重的单一感染性病原体传染性疾病,给人类带来严重的社会和经济问题。卡介苗(BCG)是目前全球唯一应用于预防结核病的疫苗,但考虑BCG疫苗对结核病保护作用时长有限,对结核杆菌潜伏感染者的结核病发病保护能力较低,以及有免疫缺陷新生儿的接种风险等问题,研发新型抗结核病疫苗势在必行。本文针对目前不同人群的结核病新疫苗研究进展进行综述,旨在为加速新疫苗的研发、对不同特征人群结核病防控提供技术支撑。

Tuberculosis(TB)is a serious contagious disease caused by a single infectious pathogen,which brings serious social and economic problems.Bacillus Calmette-Guérin(BCG)vaccine is currently the only licensed vaccine for preventing TB.However,considering the limited protective duration of the BCG vaccine,low protection ability against TB in latent TB infection,and the vaccination risk of newborns with immunodeficiency,it is imperative to study a new anti-tuberculosis vaccine.The purpose of this review is to summarize current progress in researches on new tuberculosis vaccine for different populations and to provide references for accelerating the research and development of new vaccines.