丁苯酞联合氯吡格雷治疗急性脑梗死的效果及对血清ox-LDL、hs-CRP、Hcy水平的影响

Effect of Butylphthalide Combined with Clopidogrel in the Treatment of Acute Cerebral Infarction and Its Effect on Serum ox-LDL,hs-CRP and Hcy Levels

目的:探讨丁苯酞联合氯吡格雷治疗急性脑梗死的效果及对血清氧化型低密度脂蛋白(ox-LDL)、超敏C反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)水平的影响。方法:选取2019年1月-2020年1月佳木斯大学附属第一医院收治的急性脑梗死患者75例,按照治疗方式分为对照组(n=37)与观察组(n=38)。两组均给予神经内科常规治疗,在此基础上,对照组给予氯吡格雷治疗,观察组给予丁苯酞+氯吡格雷治疗。比较两组临床疗效,美国国立卫生院神经功能缺损评分(NIHSS),日常生活能力(Barthel指数),血清ox-LDL、hs-CRP、Hcy水平及不良反应发生情况。结果:观察组总有效率为97.37%高于对照组的78.38%(P<0.05)。治疗前,两组NIHSS、Barthel指数评分,ox-LDL、hs-CRP、Hcy水平比较,差异均无统计学意义(P>0.05);治疗后,观察组Barthel指数评分高于对照组,NIHSS评分及血清ox-LDL、hs-CRP、Hcy水平均低于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:丁苯酞联合氯吡格雷治疗急性脑梗死效果显著,可改善患者神经功能,提高日常生活能力,其机制可能与降低血清ox-LDL、hs-CRP、Hcy水平有关。

Objective:To investigate the effect of Butylphthalide combined with Clopidogrel in the treatment of acute cerebral infarction and its effect on serum oxidized low-density lipoprotein(ox-LDL),high-sensitivity C-reactive protein(hs-CRP),homocysteine(Hcy)level of influence.Method:A total of 75 patients with acute cerebral infarction admitted to our hospital from January 2019 to January 2020 were selected,they were divided into the control group(n=37)and the observation group(n=38)according to the treatment method.Both groups were given conventional neurology treatment,on this basis,the control group was given Clopidogrel treatment,and the observation group was given Butylphthalide+Clopidogrel treatment.Efficacy,the national institutes of health neurological impairment score(NIHSS),ability of daily living(Barthel indexs),serum ox-LDL,hs-CRP,Hcy levels and adverse reactions were compared.Result:The total effective rate of the observation group was 97.37%,higher than 78.38%of the control group(P<0.05).Before treatment,there were no significant difference in NIHSS,Barthel indexe scores and ox-LDL,hs-CRP and Hcy levels between the two groups(P>0.05);after treatment,the Barthel indexe score of the observation group was higher than that of the control group,and the NIHSS score,serum ox-LDL,hs-CRP and Hcy levels were lower than those of the control group(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion:Butylphthalide combined with Clopidogrel in the incidence of treatment of acute cerebral infarction can improve the curative effect,improve the patient’s nerve function,and improve the ability of daily living,the mechanism may be related to the reduction of serum ox-LDL,hs-CRP,and Hcy levels.