丹红注射液对未溶栓治疗的急性脑梗死合并高血脂患者临床效果及出血转化的影响

Clinical Effect of Danhong Injection in the Treatment of Patients with Acute Cerebral Infarction Complicated with Hyperlipidemia without Thrombolytic Therapy and the Influence of Hemorrhage Transformation

目的:探讨丹红注射液对未溶栓治疗的急性脑梗死合并高血脂患者临床效果及出血转化的影响。方法:选取2019年6月-2020年12月本院收治的150例未溶栓治疗的急性脑梗死合并高血脂患者,根据随机数字表法将其分为对照组和观察组,每组75例。对照组在常规治疗的基础上加用瑞舒伐他汀,观察组在对照组的基础上加用丹红注射液。比较两组的临床疗效、神经功能评分、血脂水平及出血转化情况。结果:观察组总有效率为94.67%高于对照组的82.67%,差异有统计学意义(P<0.05)。治疗前,两组CSS、NIHSS评分比较,差异均无统计学意义(P>0.05);治疗后,两组的CSS、NIHSS评分均低于治疗前,观察组均低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组HDL-C、LDL-C、TC、TG水平比较,差异均无统计学意义(P>0.05);治疗后,两组HDL-C水平均高于治疗前,LDL-C、TG及TC水平均低于治疗前,且观察组HDL-C水平高于对照组,LDL-C、TG及TC水平均低于对照组,差异均有统计学意义(P<0.05)。观察组的出血转化率为6.67%,低于对照组的17.33%,差异有统计学意义(P<0.05)。结论:丹红注射液在未溶栓治疗的急性脑梗死合并高血脂患者中的应用效果较好,有助于改善患者神经功能水平,调节血脂,并且控制出血转化。

Objective:To investigate the clinical effect of Danhong Injection in the treatment of patients with acute cerebral infarction complicated with hyperlipidemia without thrombolytic therapy and its influence of hemorrhagic transformation.Method:A total of 150 patients with acute cerebral infarction complicated with hyperlipidemia without thrombolytic therapy admitted to our hospital from June 2019 to December 2020 were selected,and they were divided into control group and observation group according to random number table method,75 cases in each group.The control group was treated with Rosuvastatin on the basis of the conventional treatment,and the observation group was treated with Danhong Injection on the basis of the control group.Clinical efficacy,neurological function level,blood lipid level and hemorrhage transformation were compared between two groups.Result:The total effective rate of observation group was 94.67%,which was higher than 82.67% of control group,the difference was statistically significant (P<0.05).Before treatment,there were no significant differences in CSS and NIHSS scores between two groups (P>0.05);after treatment,the CSS and NIHSS scores of both groups were lower than those before treatment,and those of the observation group were lower than those of the control group,the differences were statistically significant (P<0.05).Before treatment,there were no significant differences in HDL-C,LDL-C,TC and TG levels between two groups (P>0.05);after treatment,HDL-C level of both groups were higher than those before treatment,LDL-C,TG and TC levels of both groups were lower than those before treatment,and HDL-C level of the observation group was higher than that of the control group,LDL-C,TG and TC levels of the observation group were lower than those of the control group,the differences were statistically significant (P<0.05).The hemorrhage transformation rate of the observation group was 6.67%,which was lower than 17.33% in the control group,the difference was statistically significant (P<0.05).Conclusion:Danhong Injection has a good effect in the treatment of patients with acute cerebral infarction combined with hyperlipidemia without thrombolysis therapy,which can improve the patient’s neurological function level,regulate blood lipids,as well as control hemorrhage transformation.