通过C(sp^(3))-H键活化构建C-P键合成氨基膦酸酯类化合物

Progress in the Synthesis of Aminophosphonates Compounds by Forming C-P Bonds via C(sp^(3))-H Activation

氨基膦酸酯及其衍生物是一类重要的有机化合物,因其具有抗菌、抗真菌、酶抑制剂和催化抗体活性而广泛应于药物化学和农业化学。通过C(sp^(3))-H键活化构建C-P键是合成氨基膦酸酯衍生物重要方法之一。本文以过渡金属体系和非金属体系进行分类,介绍了近年来通过C(sp^(3))-H键活化方法构建C-P键合成氨基膦酸酯类化合物的研究进展。

Amino phosphonates and their corresponding amino phosphonic acids are important organic compounds. Moreover, α-amino phosphonates have broad applications ranging from pharmaceutical chemistry to agricultural chemistry due to their antibacterial, antifungal, enzyme inhibitory, and catalytic antibody activities. It is a primary method for synthesizing functional amino phosphonate compounds using transition metal-catalyzed and metal-free catalyzed by cross-coupling reaction to form C-P bond. It is undeniably attractive to synthesize amino phosphonate compounds by forming C-P bonds via C(sp^(3))-H activation. This paper summarizes the recent advances in synthesizing amino phosphonate compounds by forming C-P bonds via C(sp^(3))-H activation. For a start, the recent advances in synthesis of amino phosphonates by forming C-P bonds via C(sp^(3))-H activation are surveyed based on various transition-metal-catalyzed and metal-free catalyzed types. Taken together, the above results have opened new avenues toward the more mild, efficient and green synthesis of essential amino phosphonate compounds.