帕金森病患者血压和治疗药物相关性的研究进展

Blood pressure and its association with antiparkinsonian medications in patients with Parkinson′s disease

帕金森病是发病率仅次于阿尔茨海默病的神经系统退行性疾病,其非运动症状越来越受到人们关注,其中血压异常的发生与诸多因素相关,包括衰老及其并发因素、帕金森病相关的自主神经功能紊乱以及左旋多巴在内的帕金森病治疗药物,且血压异常严重限制了临床上抗帕金森病药物的使用。为了更好地了解帕金森病治疗药物与帕金森病患者血压的关系,文中总结了帕金森病血压异常的表现,分析了以左旋多巴为主的帕金森病治疗药物与患者血压变化的相关性,归纳了左旋多巴等抗帕金森病药物对帕金森病血压影响的可能机制。

Parkinson′s disease(PD)is the second most common neurodegenerative disease following Alzheimer′s disease.The non-motor symptoms of PD have attracted increasing attention.The occurrence of abnormal blood pressure is related to many factors,including aging,PD related autonomic nerve dysfunction,and drugs for PD treatment,including levodopa,dopamine receptor agonists.Abnormal blood pressure severely limits the clinical use of anti-PD drugs.In order to better understand the relationship between anti-PD drugs and blood pressure in patients with PD.This article summarizes the manifestations of abnormal blood pressure,and analyzes the correlation between anti-PD drugs and blood pressure,summarizes the possible mechanisms of how anti-PD drugs affects the blood pressure in PD.