激素治疗绝经泌尿生殖综合征的疗效

Efficiency of hormone therapy for genitourinary syndrome of menopause

目的观察激素治疗绝经泌尿生殖综合征的疗效。方法收集2018年9月—2019年8月于该院更年期门诊就诊的绝经泌尿生殖综合征患者65例,均予以激素补充治疗,在治疗前、治疗1个月及3个月后采用症状评分和阴道黏膜评分评估患者的泌尿生殖道症状和体征。结果65例患者治疗前、治疗1个月及3个月后的症状评分分别为(2.60±0.58)分、(1.58±0.61)分及(1.32±0.64)分,三者分别比较,差异均有统计学意义(均P<0.05);治疗前、治疗1个月及3个月后的阴道黏膜评分分别为(7.20±1.78)分、(5.18±1.58)分及(4.52±1.49)分,三者分别比较,差异均有统计学意义(均P<0.05)。结论激素治疗能有效改善绝经泌尿生殖综合征,在缓解相关症状的同时对阴道萎缩也有积极作用。

Objective To observe the efficacy of hormone therapy for genitourinary syndrome of menopause(GSM).Methods 65 postmenopausal women with GSM in our department from September 2018 to August 2019 were enrolled in the study.All the patients accepted hormone replacement therapy and assessment was conducted at baseline,1 month and 3 months after treatment.The severity of GSM was evaluated by a self-assessment 4-point scale and vaginal mucosa assessment scale.Results The scores of genitourinary symptoms at baseline,1 month and 3 months were(2.60±0.58)points,(1.58±0.61)points and(1.32±0.64)points,and there were significant differences among the three groups(P<0.05).The scores of vaginal mucosa at baseline,1 month and 3 months were(7.20±1.78)points,(5.18±1.58)points and(4.52±1.49)points,and also there were significant differences among the three groups(P<0.05).Conclusion Hormone therapy can not only effectively improve genitourinary syndrome of menopause,but also play a positive role in changing vaginal atrophy.