CYP2C19基因多态性与汉族妇女产后抑郁症的关系

Relationship between CYP2C19 gene polymorphism and postpartum depression in Han women

目的分析细胞色素P4502C19(CytochromeP4502C19,CYP2C19)基因多态性与汉族妇女产后抑郁症的关系。方法选取282例汉族产后妇女,取外周血采用多聚酶链式反应(PCR)和脱氧核糖核酸(DNA)微阵列芯片法检测CYP2C19基因多态性。统计产后抑郁症的发生率;对比产后抑郁症发生患者和未发生者CYP2C19基因多态性;采用Logistic多元回归分析探讨汉族妇女产后抑郁症易感性的影响因素。结果产后抑郁症的发生率为20.92%;产后抑郁症患者CYP2C19基因强代谢型占比及强代谢型中*1/*2和*1/*3占比均低于未发生抑郁症者(P<0.05);产后抑郁症患者CYP2C19基因弱代谢型占比及弱代谢型中*2/*2、*3/*3和*2/*3占比均高于产后未发生抑郁症者(P<0.05);有抑郁症家族史、家庭关系不和睦、睡眠质量差、近6个月内遭遇负性生活事件、CYP1C19基因弱代谢型突变纯合型和突变杂合型均是汉族妇女产后抑郁症发生的危险因素(P<0.05)。结论产后妇女有抑郁症风险,此类患者CYP2C19基因弱代谢型占比高,且弱代谢型突变纯合型及突变杂合型均是汉族妇女产后抑郁症易感性的危险因素。

Objective To analyze the relationship between cytochrome P4502 C19(CYP2 C19) gene polymorphism and the postpartum depression in Han women. Methods 282 postpartum women of Han nationality were selected. Peripheral blood samples were collected to detect CYP2 C19 gene polymorphism by polymerase chain reaction(PCR) and deoxyribonucleic acid(DNA) microarray. The incidence of postpartum depression was analyzed. The CYP2 C19 gene polymorphism was compared between the patients with and without postpartum depression. The risk factors of postpartum depression in Han women were analyzed by logistic multiple regression analysis. Results The incidence of postpartum depression was 20.92%.The proportion of CYP2 C19 gene strong metabolic type and the proportion of *1/*2 and *1/*3 of the strong metabolic type in patients with postpartum depression were lower than those without postpartum depression(P<0.05). The proportion of CYP2 C19 gene weak metabolic type and the proportion of *2/*2, *3/*3 and *2/*3 of the weak metabolic type in patients with postpartum depression were higher than those without postpartum depression(P<0.05). Family history of depression, disharmony of family relationship, poor sleep quality, negative life events in recent 6 months, homozygous and heterozygous mutations of CYP2 C19 gene were risk factors for postpartum depression in Han women(P<0.05). Conclusion Postpartum women are at risk of depression, and the proportion of CYP2 C19 gene weak metabolic type is high, and homozygous and heterozygous of CYP2 C19 weak metabolic type mutation are the risk factors of postpartum depression in Han women.