4-溴-2-(二苄基氨基)丁酸甲酯的简便合成

Simple Synthesis of Methyl 4-Bromo-2-(dibenzylamino)butyrate

本文以商业的高丝氨酸为起始原料,通过溴代反应、酯化反应、还原缩合反应、取代反应等步骤,成功合成了4-溴-2-(二苄基氨基)丁酸甲酯。采用核磁共振氢谱(1H NMR)和碳谱(13CNMR)对目标产物进行了表征。此合成方法为γ-溴氨基酸酯结构的药物分子的合成提供了一条便利途径。

Methyl 4-bromo-2-(dibenzylamino)butyrate was synthesized from commercially available homoserine by bromination,esterification,reduction condensation and substitution.The target products were characterized by 1H NMR and 13C NMR.This synthetic method provided a convenient way for the synthesis of drug molecules withγ-bromoamino acid ester structure.