基于共价有机框架材料的纳米体系在生物医学中的应用

Application of Covalent Organic Framework-Based Nanosystems in Biomedicine

共价有机框架(Covalent organic frameworks,COFs)材料是通过动态共价化学法合成的一种高度有序的多孔晶态有机聚合物。COFs材料具有密度低、比表面积大、孔隙度可调、合成路线简单多样、功能单元和结构可设计、表面及孔道易功能化、物理化学稳定性高等主要特征,在分子吸附与分离、储能、光电、传感、催化、色谱材料、水处理材料和生物医学等方面受到了广泛关注。本文重点综述近年来基于COFs材料的体系在生物检测和成像、药物输送、光学治疗和联合治疗等生物医学领域的研究进展,并总结了目前COFs材料在生物医学领域所面临的挑战和未来的发展机遇。

Covalent organic frameworks(COFs)is a highly ordered crystalline porous polymer synthesized by dynamic covalent chemical method.Low density,large specific surface area,adjustable porosity,simple and diverse synthesis routes,designable functional units and structures,easy functionalization of surface and pore channels,and high physicochemical stability are the main characteristics of COFs.It has received extensive attention in molecular adsorption and separation,energy storage,photoelectricity,sensing,catalysis,chromatography materials,water treatment materials and biomedicine domains.This paper focuses on the recent research progress of COFs-based nanosystems in biomedical fields,such as biological detection and imaging,drug delivery,optical therapy and combination therapy,and finally summarize the current challenges and future development opportunities of COFs in biomedical field.