补肾平喘颗粒结合西医常规疗法治疗肾虚型支气管哮喘慢性持续期临床研究

Clinical study of kidney-invigorating and asthma-relieving granules in treating kidney deficiency type of bronchial asthma patients in persistent

目的:评价补肾平喘颗粒治疗肾虚型支气管哮喘慢性持续期患者的临床疗效。方法:将符合入选标准的2020年3-8月上海中医药大学附属市中医医院肺病科门诊支气管哮喘患者100例,采用随机、双盲、安慰剂对照的方法分为2组,每组50例。在常规治疗基础上,治疗组加用补肾平喘颗粒剂,对照组加服补肾平喘颗粒模拟剂。2组均治疗6周。观察治疗前后哮喘症状积分、哮喘控制测试表(Asthma Control Test,ACT)评分、呼气峰流速占预计值百分比(Peak expiratory flow/predicted value,PEF%)及外周血嗜酸性粒细胞(EOS)水平。结果:共91例患者完成临床研究,其中对照组45例,治疗组46例。治疗组总有效率为93.5%(43/46)、对照组为77.8%(35/45),2组比较差异有统计学意义(χ^(2)=4.579,P=0.032)。治疗后,治疗组中医证候积分、ACT量表评分、PEF水平均高于对照组(t值分别为2.802、3.420、8.938,P值均<0.01),EOS水平低于对照组(t=3.481,P=0.001)。结论:补肾平喘颗粒结合西医常规疗法可有效改善肾虚型支气管哮喘慢性持续期患者的临床症状及哮喘控制水平,提高PEF水平,减轻气道炎症。

Objective:To evaluate the clinical efficacy of kidney-invigorating and asthma-relieving granules in treating kidney deficiency type of bronchial asthma patients in persistent.Methods:A total of 100 patients with bronchial asthma admitted to Shanghai Municipal Hospital of TCM from March 2020 to August 2020 were selected as the research subjects.The patients were divided into control group and treatment group by random and double blind method,50 in each group.Both groups were treated by routine basic treatment.The control group was treated with Kidney-invigorating and asthma-relieving Placebo,while the observation group was treated with kidney-invigorating and asthma-relieving granules.All the treatment lasted for 6 weeks.The TCM syndromes scores,Asthma Control Test(ACT)scores,Peak expiratory flow/predicted value(PEF%)and eosinophil in peripheral blood before and after treatment were observed.Results:A total of 91 patients completed the clinical study.There were 45 patients in the control group and 46 in the treatment group.The total effective rate in the treatment group was 93.5%(43/46),while that in the control group was 77.8%(35/45),and the difference was statistically significant(χ^(2)=4.579,P=0.032).After the treatment,the scores of integral efficacy on syndromes in Chinese medicine,ACT and PEF%in the treatment group were significantly higher than those in the control group(t values were 2.802,3.420 and 8.938,respectively,all Ps<0.01).The eosinophil in peripheral blood of patients in the treatment group was significantly lower than that of the control group(t=3.481,P=0.001).Conclusion:On the basis of conventional treatment of western medicine,kidney-invigorating and asthma-relieving granules can relieve the clinical symptoms of asthma,improve the control level of asthma,enhance the level of PEF,reduce airway inflammation.