期刊文献+

表观遗传与肺癌耐药

Epigenetics and drug resistance in lung cancer
原文传递
导出
摘要 肺癌死亡率位居恶性肿瘤之首, 当前肺癌治疗中发生耐药是困阻临床工作者的重大难题。近年研究发现表观遗传学与肺癌耐药联系密切, 尤其在DNA甲基化、组蛋白修饰以及非编码RNA调节中发挥重要作用。通过以上三个特征探讨影响肺癌耐药的机制, 并针对机制探讨能有效改善肺癌耐药的药物, 可为临床工作中肺癌耐药相关问题提供解决思路, 对肺癌患者预后评估提供参考。 Lung cancer has the highest mortality rate among malignant tumors,and drug resistance in lung cancer treatment is currently a major challenge for clinical practitioners.Recent studies have found that epigenetics is closely linked to drug resistance in lung cancer,especially in DNA methylation,histone modifications and non-coding RNA regulation.By exploring the mechanisms affecting drug resistance in lung cancer through the above three features and exploring drugs that can effectively improve drug resistance in lung cancer in response to the mechanisms,it can provide ideas for solving the problems related to drug resistance in lung cancer in clinical work and provide a reference basis for prognostic assessment of lung cancer patients.
作者 何苗 范奎 曹芳 He Miao;Fan Kui;Cao Fang(First School of Clinical Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;First Department of Radiotherapy and Chemotherapy,Cangzhou Hospital of Integrated TCM-WM·Hebei,Cangzhou 061000,China;Department of Oncology,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China)
出处 《国际肿瘤学杂志》 CAS 2021年第10期622-626,共5页 Journal of International Oncology
基金 山东省中医药科技发展计划(2019-0081)。
关键词 DNA甲基化 组蛋白类 微RNAS RNA 长链非编码 肺肿瘤 DNA methylation Histones MicroRNAs RNA long noncoding Lung neoplasms
  • 相关文献

参考文献2

  • 1H.Agakishiev,M.M.Aggarwal,Z.Ahammed,A.V.Alakhverdyants,I.Alekseev,J.Alford,B.D.Anderson,C.D.Anson,D.Arkhipkin,G.S.Averichev,J.Balewski,D.R.Beavis,N.K.Behera,R.Bellwied,M.J.Betancourt,R.R.Betts,A.Bhasin,A.K.Bhat,H.Bichsel,J.Bieleik,J.Bielcikova,B.Biritz,L.C.Bland,W.Borowski,J.Bouchet,E.Braidot,A.V.Brandin,A.Bridgeman,S.G.Brovko,E.Bruna,S.Bueltmann,I.Bunzarov,T.P.Burton,X.Z.Cai,H.Caines,M.Calderon de la Barca Sanchez,D.Cebra,R.Cendejas,M.C.Cervantes,Z.Chajecki,P.Chaloupka,S.Chattopadhyay,H.F.Chen,J.H.Chen,J.Y.Chen,L.Chen,J.Cheng,M.Cherney,A.Chikanian,K.E.Choi,W.Christie,P.Chung,M.J.M.Codrington,R.Corliss,J.G.Cramer,H.J.Crawford,S.Dash,A.Davila Leyva,L.C.De Silvat,R.R.Debbe,T.G.Dedovich,A.A.Derevschikov,R.Derradi de Souza,L.Didenko,P.Djawotho,S.M.Dogra,X.Dong,J.L.Drachenberg,J.E.Draper,J.C.Dunlop,L.G Efimov,M.Elnim,J.Engelage,G Eppley,M.Estienne,L.Eun,O.Evdokimov,R.Fatemi,J.Fedorisin,A.Feng,R.G.Fersch,P.Filip,E.Finch,V.Fine,Y.Fisyak,C.A.Gagliardi,D.R.Gangadharan,A.Geromitsos,F.Geurts,P.Ghosh,Y.N.Gorbunov,A.Gordon,O.Grebenyuk,D.Grosnick,S.M.Guertin,A.Gupta,W.Guryn,B.Haag,O.Hajkova,A.Hamed,L-X.Han,J.W.Harris,J.P.Hays-Wehle,M.Heinz,S.Heppelmann,A.Hirsch,E.Hjort,G.W.Hoffmann,D.J.Hofiman,B.Huang,H.Z.Huang,T.J.Humanic,L.Huo,G.Igo,P.Jacobs,W.W.Jacobs,C.Jena,F.Jin,J.Joseph,E.G.Judd,S.Kabana,K.Kang,J.Kapitan,K.Kauder,H.Ke,D.Keane,A.Kechechyan,D.Kettler,D.P.Kikola,J.Kiryluk,A.Kisiel,V.Kizka,A.G.Knospe,D.D.Koetke,T.Kollegger,J.Konzer,I.Koralt,L.Koroleva,W.Korsch,L.Kotchenda,V.Kouchpil,P.Kravtsov,K.Krueger,M.Krus,L.Kumar,P.Kurnadi,M.A.C.Lamont,J.M.Landgraf,S.LaPointe,J.Lauret,A.Lebedev,R.Lednicky,J.H.Lee,W.Leight,M.J.LeVine,C.Lil,L.Li,N.Li,W.Li,X.Li,X.Li,Y.Li,Z.M.Li,M.A.Lisa,F.Liu,H.Liu,J.Liu,T.Ljubicic,W.J.Llope,R.S.Longacre,W.A.Love,Y.Lu,E.V.Lukashov,X.Luo,G.L.Ma,Y.G.Mai,D.P.Mahapatra,R.Majka,O.I.Mall,L.K.Mangotra,R.Manweiler,S.Margetis,C.Markert,H.Masui,H.S.Matis,Yu.A.Matulenko,D.MeDonald,T.S.McShane,A.Meschanin,R.Milner,N.G.Minaev,S.Mioduszewski,A.Mischke,M.K.Mitrovski,B.Mohanty,M.M.Mondal,B.Morozov,D.A.Morozov,M.G.Munhoz,M.Naglis,B.K.Nandi,T.K.Nayak,P.K.Netrakanti,L.V.Nogach,S.B.Nurushev,G.Odyniec,A.Ogawa,Oh,Ohlson,V.Okorokov,E.W.Oldag,D.Olsont,M.Pachr,B.S.Page,S.K.Pal,Y.Pandit,Y.Panebratsev,T.Pawlak,H.Pei,T.Peitzmann,C.Perkins,W.Peryt,S.C.Phatak,P.Pile,M.Planinic,M.A.Ploskon,J.Pluta,D.Plyku,N.Poljak,A.M.Poskanzer,B.V.K.S.Potukuchi,C.B.Powell,D.Prindle,N.K.Pruthi,A.M.Poskanzer,B.V.K.S.Potukuchi,B.Powell,D.Prindle,N.K.Pruthi,P.R.Pujahar,J.Putschke,H.Qiu,R.Raniwala,S.Raniwala,R.L.Ray,R.Redwine,R.Reed,H.G.Riter,J.B.Roberts,O.V.Rogachevskiy,J.L.Romero,A.Rose,L.Ruan,J.Rusnak,N.R.Sahoo,S.Sakai,I.Sakrejda,T.Sakuma,S.Salur,J.Sandweiss,E.Sangaline,A.Sarkar,J.Schambach,R.P.Scharenberg,A.M.Schmah,N.Schmitz,T.R.Schuster,J.Seele,J.Seger,I.Selyuzhenkov,P.Seyboth,E.Shahaliev,M.Shao,M.Sharma,S.S.Shi,Q.Y.Shou,E.P.Sichtermann,F.Simon,R.N.Singaraju,M.J.Skoby,N.Smirnov,H.M.Spinka,B.Srivastava,T.D.S.Stanislaus,D.Staszak,S.G.Steadman,J.R.Stevens,R.Stock,M.Strikhanov,B.Stringfellow,A.A.P.Suaide,M.C.Suarez,N.L.Subba,M.Sumbera,X.M.Sun,Y.Sun,Z.Sun,B.Surrow,D.N.Svirida,T.J.M.Symons,A.Szanto de Toledo,J.Takahashi,A.H.Tang,Z.Tang,L.H.Tarini,T.Tarnowsky,D.Thein,J.H.Thomas,J.Tian,A.R.Timmins,D.Tlusty,M.Tokarev,V.N.Tram,S.Trentalange,R.E.Tribble,Tribedy,O.D.Tsai,T.Ullrich,D.G.Underwood,G.Van Buren,G.van Nieuwenhuizen,J.A.Vanfossen,R.Varma,G.M.S.Vasconcelos,A.N.Vasiliev,F.Videbaek,Y.P.Viyogi,S.Vokal,M.Wadat,M.Walker,F.Wang,G.Wang,H.Wang,J.S.Wang,Q.Wang,X.L.Wang,Y.Wang,G.Webb,J.C.Webb,G.D.Westfall,C.Whitten,H.Wieman,S.W.Wissink,R.Witt,W.Witzke,Y.F.Wu,Xiao,W.Xie,H.Xu,N.Xu,Q.H.Xu,W.Xu,Y.Xu,Z.Xu,L.Xue,Y.Yang,P.Yepes,K.Yip,I-K.Yoo,M.Zawisza,H.Zbroszczyk,W.Zhan,J.B.Zhang,S.Zhang,W.M.Zhang,X.P.Zhang,Y.Zhang,Z.P.Zhang,J.Zhao,C.Zhong,W.Zhou,X.Zhu,Y.H.Zhu,R.Zoulkarneev,Y.Zoulkarneeva.Measurements of dihadron correlations relative to the event plane in Au+Au collisions at√^(S)NN=200 GeV[J].Chinese Physics C,2021,45(4):198-241. 被引量:351
  • 2李智,许静凯,张博.长非编码RNA在肿瘤中的作用机制[J].国际肿瘤学杂志,2018,45(4):220-222. 被引量:4

二级参考文献1

共引文献353

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部