阻塞性睡眠呼吸暂停低通气综合征基因多态性的研究进展

Research progress of gene polymorphism in obstructive sleep apnea hypopnea syndrome

阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是由夜间反复发作的间歇性缺氧和睡眠结构紊乱引起, 可导致多系统功能障碍, 严重降低患者的生活质量, 缩短患者的寿命。随着经济的发展, 肥胖人数也在增加, OSAHS患病率也在逐渐上升, 但是OSAHS发病机制仍不十分清楚。国内外学者已经从基因层面研究OSAHS的发病机制。现就OSAHS基因多态性的研究进展予以综述。

Obstructive sleep apnea hypopnea syndrome(OSAHS)is caused by repeated episodes of intermittent hypoxia and sleep structure disorder at night,which can cause multiple-system dysfunction,seriously reducing the quality of patient life and shortening the life of patients.With the development of economy,both the number of obese people and the prevalence of OSAHS are increasing,but the pathogenesis of OSAHS remains not very clear.Scholars at home and abroad have studied the pathogenesis of OSAHS from the genetic level.This article will review the research progress of OSAHS gene polymorphism.