抑郁症治疗前后C反应蛋白水平的变化及与临床疗效的关系

Changes of C-reactive protein levels before and after treatment in patients with depression and its relationship with clinical efficacy

目的探讨抑郁症治疗前后血清超敏C反应蛋白(hs-CRP)水平变化及其与疗效的相关性。方法选取抑郁症住院患者91例(研究组),健康对照82名(对照组),分别测定其入院时及出院前后2周内血清hs-CRP水平,比较入院前后hs-CRP水平的变化及与健康对照的差异,并分析影响疗效的临床因素。结果研究组急性期hs-CRP水平低于对照组(P<0.05),治疗后缓解期hs-CRP水平与对照组比较差异无统计学意义(P>0.05)。研究组缓解期hs-CRP水平较急性期升高(P<0.05)。将研究组按照疗效分成好转组和治愈组,两组患者性别构成比、起病年龄、病程、急性期hs-CRP水平的差异均无统计学意义(P>0.05)。以性别进行分组然后统计分析,组间比较发现不同性别的抑郁症患者疗效也与急性期hs-CRP水平无相关性(P>0.05)。结论抑郁症急性期hs-CRP水平下降,急性期hs-CRP水平与疗效不相关。

Objective To explore the changes of serum hypersensitive C-reactive protein(hs-CRP)levels before and after treatment in patients with depression and its relationship with therapeutic effect.Methods 91 inpatients with depression in study group and 82 healthy controls in control group were selected and their serum levels of hs-CRP were measured at admission and within 2 weeks before and after discharge.The changes of hs-CRP levels before and after admission as well as the differences between study group and control group were compared,and to analyze the clinical factors affecting the efficacy.Results The serum level of hs-CRP in study group in acute phase was significantly lower than that in control group(P<0.05).There existed no difference in serum levels of hs-CRP between study group in remission phase and control group(P>0.05).In study group,the serum level of hs-CRP in remission phase was significantly higher than that in acute phase(P<0.05).There existed no significant differences in the gender ratios,onset ages,illness durations and serum levels of hs-CRP in acute phase between patients in improvement group and recovery group(P>0.05).Between depressive patients with different genders,there was no correlation between efficacies and serum levels of hs-CRP in acute phase(P>0.05).Conclusion The levels of hs-CRP in acute phase of depression may decrease,which are not related to the treatment efficacy.