短疗程阿奇霉素对轻症肺炎支原体肺炎患儿症状消退及炎症因子水平的影响

Effect of short course of Azithromycin on symptom remission and levels of inflammatory factors in children with mild mycoplasma pneumoniae pneumonia

目的探讨短疗程阿奇霉素对轻症肺炎支原体肺炎(MPP)患儿症状消退及炎症因子水平的影响。方法选取2018年1月至2019年12月高安市妇幼保健院儿科的120例轻症MPP患儿作为研究对象,采用随机数字表法将其分为对照组和观察组,每组各60例。对照组采用长疗程阿奇霉素(7 d)治疗,观察组采用短疗程阿奇霉素(5 d)治疗。比较两组症状消退时间、治疗前后血清炎症因子水平变化及不良反应总发生率。结果两组咳嗽消失时间和肺部啰音消失时间比较,差异无统计学意义(P>0.05)。两组治疗后血清C反应蛋白(CRP)、白细胞计数(WBC)水平低于治疗前,差异有统计学意义(P<0.05);治疗后两组的血清CRP、WBC水平比较,差异无统计学意义(P>0.05)。观察组不良反应总发生率(8.33%)低于对照组(21.67%),差异有统计学意义(P<0.05)。结论短疗程阿奇霉素治疗轻症MPP患儿的疗效与长疗程阿奇霉素相似,均可降低患儿炎症因子水平,且症状消退时间短,不良反应发生较少,安全性高。

Objective To investigate the effect of short course of Azithromycin on symptom remission and levels of inflammatory factors in children with mild mycoplasma pneumoniae pneumonia(MMP).Methods A total of 120 children with mild MPP in the Department of Pediatrics,Gao′an Maternal and Child Health Care Hospital from January 2018 to December 2019 were selected as the research subjects.They were divided into control group and observation group by random number table method,with 60 cases in each group.The control group was treated with long-term Azithromycin(7 days),and the observation group was treated with short-term Azithromycin(5 days).The time of symptom regression,the level of serum inflammatory factors before and after treatment and the total incidence of adverse reactions were compared between the two groups.Results There was no significant difference in the disappearance time of cough and lung rales between the two groups(P>0.05).The levels of serum C-reactive protein(CRP)and white blood cell count(WBC)in two groups after treatment were lower than before,the differences were statistically significant(P<0.05).There was no statistical difference in the levels of serum CRP and WBC between two groups after treatment(P>0.05).The total incidence of adverse reactions in observation group(8.33%)was lower than that in control group(21.67%),the difference was statistically significant(P<0.05).Conclusion The efficacy of short course of Azithromycin in the treatment of children with mild MPP is similar to that of long course of azithromycin,which can reduce the level of inflammatory factors in children with short symptom resolution time,less adverse reactions,and high safety.