低浓度苯暴露人群遗传损伤与表观遗传改变研究进展

Advances in Genetic Damages and Epigenetic Changes in Populations Exposed to Low-Concentration Benzene

长期职业性接触苯与急性骨髓性白血病等血液恶性肿瘤的风险增加有关。越来越多的研究表明:职业人群低浓度苯暴露(时间加权平均容许浓度小于6 mg/m,苯暴露短时间接触浓度小于10 mg/m;)也会造成机体损伤。遗传损伤和表观遗传调控作为化学物致癌的主要机制受到人们的关注。本文就低浓度苯暴露的遗传损伤与表观遗传变化的人群研究作以综述,主要内容包括遗传损伤(染色体损伤、DNA损伤及修复、端粒长度改变)和表观遗传改变(DNA甲基化、组蛋白修饰、非编码RNA),以期为后续低浓度苯相关研究提供线索。

Long-term occupational exposure to benzene is associated with an increased risk of hematologic malignancies such as acute myeloid leukemia. More and more studies have shown that occupational exposure to low-concentration benzene(time-weighted average allowable concentration less than 6 mg/m;and short-term benzene exposure concentration less than 10 mg/m;) may also cause physical damages. Genetic damages and epigenetic regulation, as the main mechanisms of chemical carcinogenesis, have attracted people’s attention. This article reviews the studies concerning populations with genetic damages and epigenetic changes after low-concentration benzene exposure;the main contents include genetic damages(chromosome damage, DNA damage and repair, and telomere length changes) and epigenetic changes(DNA methylation, histone modification, and non-coding RNA), aiming to provide clues for subsequent studies related to low-concentration benzene.