难治性哮喘患者血清CRP、ENO1、MPO、SERPINE1表达水平及与预后的关系

Expressions of Serum CRP,ENO1,MPO and SERPINE1 and Their Relationships with Prognoses in Patients with Refractory Asthma

目的探讨难治性哮喘患者血清C反应蛋白(CRP)、烯醇化酶1(ENO1)、髓过氧化物酶(MPO)、纤溶酶原激活物抑制因子1(SERPINE1)表达水平及与预后的关系。方法回顾性分析2016年6月—2019年6月收治的难治性哮喘120例的临床资料,根据随访6个月时患者哮喘控制测试问卷(ACT)得分分为预后良好组74例和预后不良组46例。比较2组一般资料及血清CRP、ENO1、MPO、SERPINE1表达水平,分析血清CRP、ENO1、MPO、SERPINE1表达水平与患者预后的关系,评估其对难治性哮喘预后的预测价值。结果与预后不良组比较,预后良好组既往重症哮喘发作次数少、既往缓解期第一秒用力呼气容积(FEV1)水平高、合并感染比例低、既往规律吸入糖皮质激素比例高、合并基础疾病比例低,血清CRP、ENO1、MPO及SERPINE1水平低(P<0.05,P<0.01)。血清CRP、ENO1、MPO及SERPINE1水平均与ACT得分呈负相关关系(r=-0.648、-0.692、-0.658、-0.616,P<0.01)。血清CRP、ENO1、MPO及SERPINE1水平是影响难治性哮喘预后的独立危险因素(P<0.05)。血清CRP、ENO1、MPO、SERPINE1是预测难治性哮喘预后的有效指标(P<0.05)。结论血清CRP、ENO1、MPO、SERPINE1表达水平与难治性哮喘患者预后关系密切。

Objective To explore expressions of C-reactive protein(CRP),enolase 1(ENO1),myeloperoxidase(MPO)and plasminogen activator inhibitor 1(SERPINE1)and their relationships with prognoses in patients with refractory asthma.Methods Clinical data of 120 patients with refractory asthma admitted between June 2017 and June 2019 was retrospectively analyzed.According to scores of asthma control test questionnaire(ACT)with follow-up for 6 months,the patients were divided into good prognosis group(n=74)and poor prognosis group(n=46).The general data and expressions of serum CRP,ENO1,MPO and SERPINE1 were compared between two groups,and relationships between expressions of CRP,ENO1,MPO and SERPINE1 with prognoses were analyzed,and then values of the above indicators in prediction of prognoses in patients with refractory asthma were evaluated.Results Compared with those in poor prognosis group,attack frequency of previous severe asthma was fewer;level of previous forced expiratory volume in one second(FEV1%)at remission stage was higher;proportion of combined infection was lower;proportion of previous regular inhaled glucocorticoids was higher;proportion of combined underlying diseases was lower,and serum levels of CRP,ENO1,MPO and SERPINE1 were lower in good prognosis group(P<0.05,P<0.01).Serum levels of CRP,ENO1,MPO and SERPINE1 were negatively correlated with ACT score(r=-0.648,-0.692,-0.658,-0.616,P<0.01).Serum levels of CRP,ENO1,MPO and SERPINE1 were independent risk factors affecting prognoses of patients with refractory asthma(P<0.05).Serum CRP,ENO1,MPO and SERPINE1 were all effective indicators for predicting prognoses of patients with refractory asthma(P<0.05).Conclusion Expressions of serum CRP,ENO1,MPO and SERPINE1 are closely related to prognoses of patients with refractory asthma.