CTRP1、HMGB1、CAM水平变化与脑卒中患者神经功能损伤程度的关系研究

Relationship between changes of CTRP 1,HMGB 1 and CAM levels and degree of neurological damage in stroke patients

目的观察脑卒中患者的肿瘤坏死因子相关蛋白(CTRP1)、高迁移率族蛋白1(HMGB1)、钙调蛋白(CAM)水平变化,并分析其与神经功能损伤程度的关系。方法选取2019年6月至2020年6月河南省直第三人民医院收治的92例脑卒中患者,设为观察组。选取同期我院体检的健康人员92例作为对照组。观察两组研究对象CTRP1、HMGB1、CAM水平,分析脑卒中患者CTRP1、HMGB1、CAM与神经功能损伤程度的相关性。结果脑卒中患者的CTRP1、HMGB1、CAM水平均高于对照组(P<0.05)。不同神经功能损伤程度患者CTRP1、HMGB1、CAM水平存在明显差异(P<0.05)。脑卒中患者的CTRP1、HMGB1、CAM水平与神经功能损伤程度呈正相关(r=0.764、0.737、0.801,P<0.05)。预后不良组患者CTRP1、HMGB1、CAM水平显著高于预后良好组(P<0.05)。结论脑卒中患者的CTRP1、HMGB1、CAM水平较高,且与患者神经功能损伤程度密切相关,可作为病情监测的重要指标。

【Objective】To observe the changes of CTRP 1,HMGB 1,and CAM levels in stroke patients,and analyze the relationship between them and the degree of neurological damage.【Methods】Ninety-two stroke patients admitted to our hospital from June 2019 to June 2020 were selected as the observation group.A total of 92 healthy persons who received physical examination in our hospital during the same period were selected as the control group.The levels of CTRP 1,HMGB 1,and CAM in the two groups were observed,and the correlation between the levels of CTRP 1,HMGB 1,and CAM in stroke patients and the degree of neurological damage were analyzed.【Results】The levels of CTRP 1,HMGB 1,and CAM in stroke patients were higher than those in the control group(P<0.05).There were significant differences in CTRP 1,HMGB 1,and CAM levels in patients with different levels of neurological impairment(P<0.05).The levels of CTRP 1,HMGB 1,and CAM in stroke patients were positively correlated with the degree of neurological damage(r=0.764,0.737,0.801,P<0.05).The levels of CTRP 1,HMGB 1 and CAM in the poor prognosis group were significantly higher than those in the good prognosis group(P<0.05).【Conclusion】The levels of CTRP 1,HMGB 1,and CAM in stroke patients are relatively high,and are closely related to the degree of neurological damage in patients,and can be used as important indicators for disease monitoring.