复方丙酸氯倍他索软膏与卡泊三醇软膏序贯疗法治疗轻、中度寻常型银屑病的临床观察

Clinical observation of sequential therapy of compound clobetasol propionate ointment and calcipotriol ointment in the treatment of mild and moderate psoriasis vulgaris

目的 探究轻、中度寻常型银屑病患者采用复方丙酸氯倍他索软膏与卡泊三醇软膏序贯疗法治疗的效果。方法 选取90例轻、中度寻常型银屑病患者作为研究对象,通过信封随机分组法分为实验组、对照Ⅰ组、对照Ⅱ组,每组30例。对照Ⅰ组患者给予复方丙酸氯倍他索软膏外涂,对照Ⅱ组患者给予卡泊三醇软膏外涂,实验组患者给予复方丙酸氯倍他索软膏与卡泊三醇软膏序贯疗法。对比三组患者治疗2、4周后银屑病面积和严重程度指数(PASI)、皮肤生活质量指数(DLQI)、银屑病静态临床医生整体评估(PGA)评分及治疗效果,分析三组患者不良反应发生情况。结果 治疗2周后,三组PASI、DLQI、PGA评分比较差异均无统计学意义(P>0.05)。治疗4周后,对照Ⅰ组的PASI、DLQI、PGA评分分别为(13.18±1.85)、(10.53±1.35)、(2.38±0.59)分,对照Ⅱ组分别为(13.49±1.59)、(10.76±1.29)、(2.34±0.62)分,实验组分别为(9.85±1.07)、(7.26±1.20)、(1.42±0.51)分,实验组的PASI、DLQI、PGA评分均低于对照Ⅰ组和对照Ⅱ组,差异均具有统计学意义(P<0.05)。实验组、对照Ⅰ组和对照Ⅱ组的治疗总有效率分别为93.33%、63.33%和63.33%,实验组的治疗总有效率高于对照Ⅰ组和对照Ⅱ组,差异具有统计学意义(P<0.05)。三组患者治疗期间均未发生与研究药物相关的不良反应,耐受性均良好。结论 在轻、中度寻常型银屑病治疗中采用复方丙酸氯倍他索软膏与卡泊三醇软膏序贯疗法可提高临床治疗效果,降低患者的皮损程度,改善生活质量,具有良好的临床推广意义。

Objective To investigate the effect of sequential therapy of compound clobetasol propionate ointment and calcipotriol ointment in the treatment of mild and moderate psoriasis vulgaris.Methods A total of 90 patients with mild and moderate psoriasis vulgaris were taken as the research subjects.They were divided into experimental group,control groupⅠ,and control groupⅡby the envelope randomization method,with 30 cases in each group.Patients in the control groupⅠreceived external application of compound clobetasol propionate ointment,patients in the control groupⅡreceived external application of calcipotriol ointment,and patients in the experimental group received sequential therapy of compound clobetasol propionate ointment and calcipotriol ointment.The psoriasis area and severity index(PASI),dermatology life quality index(DLQI),physician global assessment(PGA)scores after 2 and 4 weeks of treatment,and therapeutic effects of the three groups were compared,and the incidences of adverse reactions of the three groups were analyzed.Results After 2 weeks of treatment,there was no statistically significant difference in PASI,DLQI,and PGA scores among the three groups(P>0.05).After 4 weeks of treatment,the PASI,DLQI,and PGA scores of the control groupⅠwere(13.18±1.85),(10.53±1.35),(2.38±0.59)points,the control groupⅡwere(13.49±1.59),(10.76±1.29),(2.34±0.62)points,and the experimental group were(9.85±1.07),(7.26±1.20),(1.42±0.51)points;the PASI,DLQI,and PGA scores of the experimental group were lower than those of the control groupⅠand control groupⅡ,and the differences were statistically significant(P<0.05).The total effective rates of treatment in the experimental group,control group I and control group II were 93.33%,63.33%,and 63.33%,respectively.The total effective rate of treatment in the experimental group was higher than that in the control groupⅠand control groupⅡ,and the difference was statistically significant(P<0.05).No drug-related adverse reactions occurred during treatment in any of the three groups,and all were well tolerated.Conclusion Sequential therapy of compound clobetasol propionate ointment and calcipotriol ointment in the treatment of mild and moderate psoriasis vulgaris can improve the clinical efficacy,reduce the degree of skin lesions and improve the quality of life of patients,which has good clinical promotion significance.