无创呼吸机治疗慢阻肺合并呼吸衰竭的临床价值及安全性分析

Clinical value and safety of non-invasive ventilator in the treatment of chronic obstructive pulmonary disease complicated with respiratory failure

目的 分析无创呼吸机治疗慢性阻塞性肺疾病(慢阻肺, COPD)合并呼吸衰竭的临床价值及安全性。方法 50例慢阻肺合并呼吸衰竭患者,采用盲选法分为常规组和试验组,每组25例。常规组给予常规治疗,试验组在常规组治疗基础上联合无创呼吸机治疗。比较两组患者治疗前后临床体征、肺功能、血气指标以及不良反应发生情况。结果 治疗后,试验组患者呼吸频率、心率以及pH值分别为(18.25±3.11)次/min、(85.33±8.76)次/min、(7.29±0.09),均低于常规组的(24.32±5.31)次/min、(98.34±10.35)次/min、(7.39±0.12),差异具有统计学意义(P<0.05)。治疗后,试验组患者第1秒用力呼气容积(FEV_(1))(2.65±0.43)L、氧分压(PaO_(2))(11.18±1.53)kPa高于常规组的(1.67±0.36)L、(7.95±1.56)kPa,二氧化碳分压(PaCO_(2))(6.67±0.76)kPa低于常规组的(7.75±0.98)kPa,差异具有统计学意义(P<0.05)。试验组患者不良反应发生率为16.00%,与常规组的4.00%比较差异无统计学意义(P>0.05)。结论 慢阻肺合并呼吸衰竭患者使用无创呼吸机可以更好的对心率等临床体征指标进行改善,提升肺功能、血气指标,治疗过程中未出现较多不良反应,患者恢复更加理想,值得推广应用。

Objective To analyze the clinical value and safety of non-invasive ventilator in the treatment of chronic obstructive pulmonary disease(COPD)complicated with respiratory failure.Methods A total of 50 patients with COPD and respiratory failure were divided into conventional group and experimental group by blind selection method,with 25 cases in each group.The conventional group received conventional treatment,and the experimental group received non-invasive ventilator treatment on the basis of the conventional group.The clinical signs,pulmonary function,blood gas indexes before and after treatment,and occurrence of adverse reactions were compared between the two groups.Results After treatment,the respiratory rate,heart rate and pH value of the experimental group were(18.25±3.11)breaths/min,(85.33±8.76)beats/min,and(7.29±0.09)respectively,which were lower than(24.32±5.31)breaths/min,(98.34±10.35)beats/min,(7.39±0.12)of the conventional group,and the difference was statistically significant(P<0.05).After treatment,the forced expiratory volume in the 1st second(FEV1)(2.65±0.43)L and arterial partial pressure of oxygen(PaO_(2))(11.18±1.53)kPa of the experimental group were higher than(1.67±0.36)L and(7.95±1.56)kPa in the conventional group,and the arterial partial pressure of carbon dioxide(PaCO_(2))(6.67±0.76)kPa was lower than(7.75±0.98)kPa of the conventional group.All the differences were statistically significant(P<0.05).The incidence of adverse reactions in the experimental group was 16.00%,which was not statistically different from 4.00% in the conventional group(P>0.05).Conclusion The use of non-invasive ventilator in patients with chronic obstructive pulmonary disease and respiratory failure can improve heart rate,pulmonary function,blood gas index of patients.There are no adverse reactions during the treatment,and the recovery is more ideal,which is worthy of promotion and application.