二甲双胍结合阿卡波糖治疗初发2型糖尿病伴高脂血症的临床效果分析

Clinical analysis of metformin combined with acarbose in the treatment of newly-diagnosed type 2 diabetes mellitus with hyperlipidemia

目的 分析二甲双胍结合阿卡波糖治疗初发2型糖尿病伴高脂血症的临床效果。方法 64例初发2型糖尿病伴高脂血症患者,随机分为对照组和观察组,每组32例。对照组给予阿卡波糖药物治疗,观察组给予二甲双胍结合阿卡波糖治疗。比较两组患者治疗前后的血糖、血脂指标以及治疗效果。结果 治疗后,观察组患者空腹血糖(FBG)(5.92±0.97)mmol/L、餐后2 h血糖(2 h PG)(8.12±0.82)mmol/L、糖化血红蛋白(HbA1c)(5.08±0.63)%均低于对照组的(8.45±1.14)mmol/L、(10.85±2.28)mmol/L、(7.13±0.76)%,差异均具有统计学意义(P<0.05)。治疗后,观察组总胆固醇(TC)(4.18±0.52)mmol/L、甘油三酯(TG)(1.67±0.43)mmol/L、低密度脂蛋白胆固醇(LDL-C)(3.18±0.64)mmol/L均低于对照组的(5.68±0.63)、(2.85±0.48)、(3.73±0.75)mmol/L,高密度脂蛋白胆固醇(HDL-C)(1.54±0.25)mmol/L高于对照组的(1.22±0.14)mmol/L,差异均具有统计学意义有(P<0.05)。观察组治疗总有效率93.8%高于对照组的75.0%,差异具有统计学意义(P<0.05)。结论 二甲双胍结合阿卡波糖治疗初发2型糖尿病伴高脂血症,可有效改善患者血糖指标与血脂指标,治疗效果显著,可在临床实践推广。

Objective To analyze the clinical effect of metformin combined with acarbose in the treatment of newly-diagnosed type 2 diabetes mellitus with hyperlipidemia.Methods A total of 64 cases of newly-diagnosed type 2 diabetes mellitus with hyperlipidemia were randomly divided into control group and observation group,with 32 cases in each group.The control group was treated with acarbose,and the observation group was treated with metformin and acarbose.The blood glucose,blood lipid indexes and therapeutic effect of the two groups were compared.Results After treatment,the fasting blood glucose(FBG)(5.92±0.97)mmol/L,2 h postprandial glucose(2 h PG)(8.12±0.82)mmol/L,and glycosylated hemoglobin(HbA1c)(5.08±0.63)%of the observation group were lower than(8.45±1.14)mmol/L,(10.85±2.28)mmol/L,and(7.13±0.76)%of the control group,and the difference was statistically significant(P<0.05).After treatment,the total cholesterol(TC)(4.18±0.52)mmol/L,triglyceride(TG)(1.67±0.43)mmol/L,and low-density lipoprotein cholesterol(LDL-C)(3.18±0.64)mmol/L of the observation group were all lower than(5.68±0.63),(2.85±0.48),and(3.73±0.75)mmol/L of the control group,and the high-density lipoprotein cholesterol(HDL-C)(1.54±0.25)mmol/L was higher than(1.22±0.14)mmol/L of the control group.All the differences were statistically significant(P<0.05).The total effective rate of treatment in the observation group was 93.8%,which was higher than 75.0%in the control group,and the difference was statistically significant(P<0.05).Conclusion Metformin in combination with acarbose can effectively improve the blood glucose and blood lipids of patients with newly-diagnosed type 2 diabetes mellitus and hyperlipidemia,and the therapeutic effect is significant,which can be promoted in clinical practice.