N-乙酰半胱氨酸联合布地奈德雾化吸入治疗支气管肺炎患儿的效果

Effects of N-acetylcysteine combined with Budesonide aerosol inhalation in treatment of children with bronchopneumonia

目的:观察N-乙酰半胱氨酸联合布地奈德雾化吸入治疗支气管肺炎患儿的效果。方法:回顾性分析2019年4月至2021年5月该院收治的100例支气管肺炎患儿的临床资料,按治疗方案不同分为对照组和观察组各50例。两组均实施常规治疗,在此基础上对照组采用布地奈德雾化吸入治疗,观察组在对照组基础上联合N-乙酰半胱氨酸雾化吸入治疗。比较两组临床疗效、临床症状消失时间和不良反应发生率。结果:观察组治疗总有效率为96.00%(48/50),高于对照组的82.00%(41/50),差异有统计学意义(P<0.05);观察组退热时间及咳嗽、咳痰、肺部啰音等临床症状消失时间均短于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:N-乙酰半胱氨酸联合布地奈德雾化吸入治疗支气管肺炎患儿,可提高治疗总有效率,缩短临床症状消失时间,效果优于单用布地奈德治疗。

Objective:To observe effects of N-acetylcysteine combined with Budesonide aerosol inhalation in treatment of children with bronchopneumonia.Methods:The clinical data of 100 children with bronchopneumonia admitted to the hospital from April 2019 to May 2021 were retrospectively analyzed.According to different treatment plans,they were divided into control group and observation group,each with 50 cases.Both groups were treated with conventional treatment.On this basis,the control group was treated with Budesonide aerosol inhalation,while the observation group was combined with N-acetylcysteine aerosol inhalation on the basis of that of the control group.The clinical efficacy,the disappearance time of clinical symptoms and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 96.00%(48/50),which was higher than 82.00%(41/50)in the control group,and the difference was statistically significant(P<0.05).The fever clearance time and the disappearance time of clinical symptoms such as cough,sputum,and lung rales in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).However,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:N-acetylcysteine combined with Budesonide aerosol inhalation in the treatment of the children with bronchopneumonia can increase the total effective rate of treatment and shorten the clinical symptoms disappearance time.Moreover,it is superior to single Budesonide treatment.