星蒌承气汤加减辅助甘露醇、胞磷胆碱治疗卒中急性期患者的效果

Effects of Xinglou Chengqi decoction in adjuvant treatment of patients with acute stroke treated with Mannitol and Citicoline

目的:观察星蒌承气汤加减辅助甘露醇、胞磷胆碱治疗卒中急性期患者的效果。方法:回顾性分析2018年1月至2020年8月该院收治的96例卒中急性期患者的临床资料,按照治疗方法不同分为对照组和观察组各48例。对照组采用甘露醇联合胞磷胆碱治疗,观察组在对照组基础上加用星蒌承气汤加减辅助治疗,比较两组临床疗效、治疗前后血液流变学指标水平、血清神经元特异性烯醇化酶(NSE)水平和中枢神经特异性(S100-β)蛋白水平。结果:观察组治疗总有效率为93.75%(45/48),高于对照组的75.00%(36/48),差异有统计学意义(P<0.05);治疗后,观察组全血高切黏度、全血低切黏度、血浆黏度和NSE、S100-β蛋白水平均低于对照组,差异有统计学意义(P<0.05)。结论:星蒌承气汤加减辅助甘露醇、胞磷胆碱治疗卒中急性期患者可提高治疗总有效率,降低血液流变学指标水平、NSE水平和S100-β蛋白水平,效果优于甘露醇联合胞磷胆碱治疗。

Objective:To observe effects of Xinglou Chengqi decoction in adjuvant treatment of patients with acute stroke treated with Mannitol and Citicoline.Methods:Clinical data of 96 patients with acute stroke admitted to our hospital from January 2018 to August 2020 were retrospectively analyzed,According to different treatment methods,they were divided into control group and observation group,each with 48 cases.The control group was treated with Mannitol combined with Citicoline,while the observation group was treated with Xinglou Chengqi decoction on the basis of those of the control group.The clinical efficacy,the blood rheological index levels before and after the treatment,the serum neuron-specific enolase(NSE)level and the central nervous system-specific(S100-β)protein levels were compared between the two groups.Results:The effective rate of treatment in the observation group was 93.75%(45/48),which was higher than 75.00%(36/48)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the whole blood high-shear viscosity,the whole blood low-shear viscosity,the plasma viscosity,and the NSE and S100-βprotein levels of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).Conclusions:Xinglou Chengqi decoction in the adjuvant treatment of the patients with acute stroke treated with Mannitol and Citicoline can increase the effective rate of treatment and reduce the levels of hemorheologic indicators,the NSE levels and the S100-βprotein levels.Moreover,it is superior to Mannitol combined with Citicoline treatment.