丙戊酸钠联合托吡酯治疗癫痫患者的疗效及对炎性反应与氧自由基水平的影响

Efficacy of Sodium Valproate Combined with Topiramate in the Treatment of Epilepsy and Its Effect on Inflammatory Response and Oxygen Free Radical Level

目的探讨丙戊酸钠联合托吡酯治疗癫痫患者的疗效及对炎性反应与氧自由基水平的影响。方法将2017年5月至2019年5月本院收治的100例癫痫患者分为两组,每组50例,单一组患者给予丙戊酸钠治疗,联合组患者在单一组基础上联合托吡酯治疗。对两组患者的治疗效果进行对比。结果联合组治疗有效率98.00%,高于单一组的86.00%,组间差异有统计学意义(P<0.05)。联合组治疗后炎性反应和氧自由基水平显著低于治疗前,且比单一组低,差异有统计学意义(P<0.05)。两组不良反应比较,差异无统计学意义(P>0.05)。结论丙戊酸钠联合托吡酯治疗癫痫患者的效果显著,可显著抑制炎性因子作,降低炎性反应,降低氧自由基作用水平。

Objective To investigate the efficacy of sodium valproate combined with topiramate in the treatment of epilepsy and its effect on inflammatory response and oxygen free radical level.Methods According to the research needs,100 epilepsy patients admitted to our hospital from May 2017 to May 2019 were divided into two groups,50 patients in each group.Among them,the single group were treated with sodium valproate,and the combined group were treated with topiramate on the basis of a single group.The therapeutic effects of two groups were compared.Results In terms of clinical efficacy,the effective rate of the combined group was 98.00%higher than 86.00%of the single group,and there was a significant difference between the two groups(P<0.05).In terms of inflammatory reaction and oxygen free radical level,the indexes in the combined group after treatment were significantly lower than those before treatment,and lower than those in the single group,with statistical significance(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion Sodium valproate combined with topiramate in the treatment of epilepsy has a significant effect,which can significantly inhibit the role of inflammatory factors,reduce inflammatory response and reduce the level of oxygen free radicals.