注射用血塞通治疗脑动脉供血不足的疗效及对血液流变学的影响

Effect of Xuesaitong injection in treatment of cerebral artery insufficiency and its influence on hemorheology

目的观察注射用血塞通治疗脑动脉供血不足的疗效及对血液流变学的影响。方法选择2018年1月-2019年4月江西省乐安县人民医院收治的脑动脉供血不足患者94例作为研究对象,采用随机数字表法分为观察组和对照组各47例。对照组采用常规治疗,观察组在对照组的基础上联合注射用血塞通治疗。治疗2周后,比较2组临床疗效,治疗前后血液流变学指标及不良反应;随访6个月,比较2组患者治疗后1、3、6个月的复发率。结果治疗2周后,观察组近期总有效率为95.75%高于对照组的70.21%(χ^(2)=10.846,P=0.001);治疗2周后,2组高切全血黏度、低切全血黏度、红细胞压积、血浆黏度、纤维蛋白原水平均低于治疗前,且观察组低于对照组(P<0.01);2组治疗过程不良反应总发生率比较差异无统计学意义(P> 0.05);随访6个月,2组治疗后1、3个月复发率比较差异无统计学意义(P> 0.05),观察组治疗后6个月复发率低于对照组(P<0.05)。结论注射用血塞通治疗脑动脉供血不足的效果较好,可降低局部血流水平,安全性较高,且能降低用药后复发率,值得推广应用。

Objective To observe the effect ofXuesaitonginjection in treatment of cerebral artery insufficiency and its influence on hemorheology.Methods A total of 94 patients with cerebral artery insufficiency admitted to Le′an County People′s Hospital, Jiangxi Province from January 2018 to April 2019 were selected as the study subjects, and they were divided into observation group and control group by random number table method, 47 cases in each group. The control group was treated with conventional methods, and the observation group was treated withXuesaitonginjection on the basis of the control group. After 2 weeks of treatment, the clinical efficacy, hemorheology indexes before and after treatment and adverse reactions were compared between the two groups. The recurrence rate of 1, 3 and 6 months after treatment were compared between the two groups.Results After 2 weeks of treatment, the total effective rate in the observation group was 95. 75%, which was higher than that in the control group 70. 21% (χ^(2)= 10. 846,P= 0. 001);After 2 weeks of treatment, high whole blood viscosity, low whole blood viscosity, hematocrit, plasma viscosity and fibrin raw water in 2 groups were lower than before, and observation group was lower than control group(P< 0. 01);There was no significant difference in the total incidence of adverse reactions between 2 groups(P> 0. 05);There were no significant difference in recurrence rate 1 and 3 months after treatment between the two groups(P> 0. 05), and the recurrence rate 6 months after treatment in the observation group was lower than that in the control group(P< 0. 05).Conclusion Xuesaitonginjection has a good effect in the treatment of cerebral artery insufficiency, which can reduce the local blood flow level, has high safety, and can reduce the recurrence rate after medication, it is worthy of popularization and application.