阿立哌唑与利培酮治疗精神分裂症的效果及对患者认知功能的改善评价

Effects of aripiprazole and risperidone in treatment of schizophrenia and improvement of patients'cognitive function

目的探讨阿立哌唑与利培酮对精神分裂症的治疗效果及治疗后患者认知功能改善效果。方法收集2019年1月至2020年1月本院收治的140例符合精神分裂症诊断标准的患者,依照随机分组原则将研究对象分为观察组(n=70)和对照组(n=70),依照用药方案不同分组,观察组采用阿立哌唑治疗,对照组采用利培酮治疗,统计并分析两种方案下精神分裂症患者的治疗总有效率及不良反应发生率。结果对照组和观察组患者治疗的总有效率分别为85.71%和81.43%,组间比较差异无统计学意义(P>0.05)。治疗前两组PANSS中阳性及阴性症状、精神病理及总分比较,差异无统计学意义(P>0.05)。治疗相同疗程后,两组患者的相关指标评分均较治疗前显著下降(P<0.05),但观察组和对照组组间指标评分比较,差异无统计学意义(P>0.05)。观察组患者消化系统症状、嗜睡及四肢震颤的不良反应发生率低于对照组,差异有统计学意义(P<0.05);两组患者在心电图变化、体重增加及肝肾功能异常发生率比较,差异无统计学意义(P>0.05)。结论在精神分裂症的应用中,阿立哌唑治疗总有效率、使用安全性均优于利培酮,在患者认知功能的改善方面疗效可观,值得在临床推广使用。

Objective To explore the therapeutic effects of aripiprazole and risperidone on schizophrenia and the improvement of patients′cognitive function after treatment.Methods A total of 140 patients with schizophrenia who met the diagnostic criteria for schizophrenia admitted to our hospital from January 2019 to January 2020 were selected.They were randomly divided into the observation group(n=70)and the control group(n=70),according to the different medication regimens.The observation group were treated with aripiprazole and the control group were treated with risperidone.The total effective rate and incidence of adverse events were summarized and compared in patients with schizophrenia under the two regimens.Results The total effective rate of treatment in the control group and observation group were 85.71%and 81.43%,respectively,without statistically significant difference(P>0.05).Before treatment,there were no significant differences in PANSS positive and negative symptoms,psychopathology,and total score between the two groups(P>0.05).After the same course of treatment,the relevant index scores in the two groups were significantly lower than those before treatment(P<0.05).There was no statistically significant difference in the index score between the observation group and the control group(P>0.05).The incidences of adverse events of digestive system symptoms,lethargy and limb tremor in the observation group were lower than those in the control group(P<0.05).There were no significant differences in the ECG changes,weight gain and incidence of abnormal liver and kidney function between the two groups(P>0.05).Conclusion Aripiprazole is better than risperidone in the treatment of schizophrenia,with higher total effective rate and safety.It has a considerable effect on the improvement of patients'cognitive function and is worthy of clinical promotion.