纳米结构酶催化剂研究进展

Advances in nanostructured enzyme catalysts

将酶负载于载体上可以提高工业应用中酶的稳定性并便于重复使用。纳米材料的发展为固定化酶提供了新的契机,利用纳米材料固定化酶有望进一步提高酶在工业环境中的催化性能、拓展固定化酶的应用范围。本文主要关注近年来在纳米结构酶催化剂方面的研究进展,重点介绍本研究组以无机晶体、金属有机骨架材料、石墨烯和功能高分子等为载体进行酶固定化以及酶催化过程多尺度分子模拟方法的研究进展,讨论了纳米结构酶催化剂的发展前景。

Loading the enzyme on the carrier can improve the stability of the enzyme in industrial applications and facilitate repeated use. Utilizing nanostructured materials for enzyme immobilization has offered unprecedented opportunities in enhancing enzyme stability in adverse conditions found in industrial practices and thus extending the application spectra of enzymatic catalysis. This review summarizes recent progress of our group in exploring nanostructured enzyme catalysts using inorganic crystals, metal-organic frameworks, graphene and environmentally responsive polymers as matrixes, as well as a new molecular simulation method that combines with Markov-state modeling for establishing a process profile with molecular insight. The prospects of the nanostructured enzyme catalysts are also discussed.