摘要
皮肤伤口愈合过程中过度的炎症反应导致异常的血管生成,或受损的血管退化阻碍了伤后愈合而形成瘢痕。瘢痕组织比正常皮肤真皮含有更多的微血管,大量研究证实了抗血管化疗法抑制病理性瘢痕的有效性。本文对近年来血管生成在瘢痕形成中的作用以及抗血管化疗法的机制进行综述,以期为瘢痕治疗提供新的靶点。
Excessive inflammatory response during skin wound healing which leads to abnormal angiogenesis or damaged blood vessel regression which hinders wound healing can lead to scar formation.Scar tissue contains more microvessels than normal dermis.Many studies have reported the effectiveness of anti-angiogenesis therapy in treating pathological scars.In this paper,the role of angiogenesis in scar formation and the mechanism of anti-angiogenesis therapy were reviewed,in order to provide new therapeutic targets for the treatment of scars.
作者
沈一蕊
丁飞雪
刘菲
杨军
SHEN Yirui;DING Feixue;LIU Fei;YANG Jun(Department of Plastic and Reconstructive Surgery,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China)
出处
《组织工程与重建外科》
CAS
2021年第6期503-506,共4页
Journal of Tissue Engineering and Reconstructive Surgery
基金
国家自然科学基金资助项目(81871576)。
关键词
瘢痕
血管化
血管内皮生长因子
Scar
Angiogenesis
Vascular endothelial growth factor
