腹针联合大黄蛰虫丸治疗糖尿病下肢动脉硬化闭塞症的疗效观察

Observations on the Clinical Efficacy of Abdominal Acupuncture plus Da Huang Zhe Chong Pill for Diabetic Lower Limb Arteriosclerosis Obliterans

目的观察孙氏腹针联合大黄蛰虫丸治疗糖尿病合并下肢动脉硬化闭塞症的临床疗效。方法纳入糖尿病下肢动脉硬化闭塞症患者99例,随机分为治疗组(50例)和对照组(49例)。两组均予口服降糖药或胰岛素注射的基础治疗,并嘱糖尿病饮食、适当运动的健康指导。对照组予口服西洛他唑治疗,治疗组予孙氏腹针联合口服大黄蛰虫丸治疗。观察治疗前后两组空腹血糖(FPG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、甘油三酯(TG)和低密度脂蛋白胆固醇(LDL-C)的变化。观察两组治疗前后动脉中-内膜厚度(IMT)、脉搏波传导速度(PWV)和踝肱指数(ABI)的变化。比较两组临床疗效。结果治疗后,两组患者FPG、HbA1c、TC、TG、LDL-C均较治疗前明显下降(P<0.05),且治疗组治疗后FPG、HbA1c、TC、TG低于对照组(P<0.05)。治疗后,两组IMT、PWV、ABI均较治疗前改善(P<0.05),且治疗组治疗后优于对照组(P<0.05)。治疗组总有效率为96.0%,对照为87.8%,差异具有统计学意义(P<0.05)。结论腹针联合大黄蛰虫丸治疗糖尿病合并下肢动脉硬化闭塞症的疗效优于单纯口服西洛他唑,可更好地改善患者血糖、血脂代谢和血管功能。

Objective To observe the clinical efficacy of Sun’s abdominal acupuncture plus Da Huang Zhe Chong pill for diabetes complicated with lower limb arteriosclerosis obliterans.Method Ninety-nine patients with diabetic lower limb arteriosclerosis obliterans were enrolled and randomized to a treatment group(50 cases)and a control group(49 cases).Both groups were given oral hypoglycemic agents or insulin injection as basic treatment,advised to eat a diabetic diet and supplied with health guidance for proper exercise.In addition,the control group received oral administration of Cilostazol and the treatment group received Sun’s abdominal acupuncture plus oral administration of Da Huang Zhe Chong Pill.Fasting blood glucose(FBG),glycosylated hemoglobin(HbA1c),total cholesterol(TC),triglyceride(TG)and low density lipoprotein cholesterol(LDL-C)were measured in the two groups before and after treatment.Arterial intima-media thickness(IMT),pulse wave velocity(PWV)and ankle-brachial index(ABI)were observed in the two groups before and after treatment.The clinical therapeutic effects were compared between the two groups.Result After treatment,FPG,HbA1c,TC,TG and LDL-C decreased significantly in the two groups of patients compared with before(P<0.05)and FPG,HbA1c,TC and TG were lower in the treatment group than in the control group(P<0.05).After treatment,IMT,PWV and ABI improved in the two groups compared with before(P<0.05)and were better in the treatment group than in the control group(P<0.05).The total efficacy rate was 96.0%in the treatment group and 87.8%in the control group with a statistically significant difference between the two groups(P<0.05).Conclusion Abdominal acupuncture plus Da Huang Zhe Chong pill is more effective than oral Cilostazol alone in treating diabetes complicated with lower limb arteriosclerosis obliterans.It can better improve blood glucose and lipid metabolism and vascular function.