穴位贴敷治疗常年性变应性鼻炎疗效观察及对血清IgE和IL-5水平的影响

Efficacy Observation of Acupoint Application for Perennial Allergic Rhinitis and Its Effects on Serum IgE and IL-5 Levels

目的观察天灸贴穴位贴敷治疗常年性变应性鼻炎(PAR)的临床疗效及其对血清IgE、IL-5水平的影响。方法将100例PAR患者随机分为天灸组和对照组,每组50例。对照组采用口服盐酸西替利嗪片治疗,天灸组采用天灸贴穴位贴敷治疗。分别于治疗后和治疗后1年,比较两组总有效率、鼻分泌物含量及血清免疫球蛋白(Ig)E、白介素(IL)-5水平。结果治疗后,两组总有效率、鼻分泌物含量比较,差异无统计学意义(P>0.05)。治疗后1年,天灸组总有效率为72.0%,高于对照组的48.0%,两组比较差异具有统计学意义(P<0.05)。治疗后1年,两组鼻分泌物含量均较同组治疗后降低(P<0.05),且天灸组低于对照组(P<0.05)。治疗后1年,两组患者血清IgE、IL-5水平均较同组治疗前明显降低(P<0.05),且天灸组低于对照组(P<0.05)。结论穴位贴敷治疗可改善PAR患者的临床症状并降低鼻分泌物含量,近期疗效与口服药物相当,远期疗效优于口服药物,可能与降低血清IgE、IL-5水平有关。

Objective To observe the clinical efficacy of acupoint application with vesiculation moxibustion plasters in treating perennial allergic rhinitis(PAR)and its effects on the levels of serum immunoglobulin E(IgE)and interleukin(IL)-5.Method One hundred PAR patients were randomized into a vesiculation moxibustion group and a control group,with 50 cases in each group.The control group was treated with oral administration of Cetirizine hydrochloride tablets,and the vesiculation moxibustion group was treated with acupoint application with vesiculation moxibustion plasters.After treatment and one year after treatment,the total effective rate,nasal secretion content,and serum IgE and IL-5 levels were compared between the two groups.Result After treatment,there were no significant differences in the total effective rate or nasal secretion content between the two groups(P>0.05).One year after treatment,the total effective rate was 72.0%in the vesiculation moxibustion group,higher than 48.0%in the control group,showing a significant between-group difference(P<0.05).One year after treatment,the nasal secretion content decreased in both groups compared with that after treatment(P<0.05),and was lower in the vesiculation moxibustion group than in the control group(P<0.05).One year after treatment,the serum IgE and IL-5 levels significantly dropped in both groups compared with those before treatment(P<0.05),and were lower in the vesiculation moxibustion group than in the control group(P<0.05).Conclusion Acupoint application can improve the clinical symptoms and reduce the nasal secretion content in PAR patients.It can produce equivalent short-term efficacy and more significant long-term efficacy compared with the oral medications,which may be associated with its down-regulation of serum IgE and IL-5 levels.