血清相关指标水平与子宫内膜异位症的相关性研究

Correlation between serum relevant indicators levels and endometriosis

目的探讨血清血管内皮生长因子(VEGF)、糖类抗原125(CA125)、可溶性细胞黏附分子1(sICAM-1)、抗子宫内膜抗体(EMAb)水平与子宫内膜异位症(EMT)的相关性。方法收集2019年7月至2020年9月浙江省丽水市中医院收治的200例EMT患者的临床资料(观察组),另收集同期本院69名体检健康女性的相关资料(对照组)。对比2组一般资料及血清VEGF、CA125、sICAM-1、EMAb水平,分析以上指标在EMT诊断中的效能,比较EMT患者不同分期或治疗前后以上指标水平变化,分析各指标与EMT分期的相关性。结果观察组入院时血清VEGF、CA125、sICAM-1、EMAb水平均显著高于对照组[(865±23)ng/L比(451±41)ng/L、(976±50)kU/L比(461±40)kU/L、(341±30)μg/L比(203±20)μg/L、(0.39±0.05)ng/L比(0.22±0.01)ng/L],差异均有统计学意义(均P<0.001)。血清VEGF、CA125、sICAM-1、EMAb联合诊断EMT的敏感度高于、曲线下面积大于单项检测,差异均有统计学意义(均P<0.05)。Ⅰ~Ⅱ期EMT患者入院时血清VEGF、CA125、sICAM-1、EMAb水平均明显低于Ⅲ~Ⅳ期,差异均有统计学意义(均P<0.001)。治疗后EMT患者血清VEGF、CA125、sICAM-1、EMAb水平均低于入院时,差异均有统计学意义(均P<0.001)。血清VEGF、CA125、sICAM-1、EMAb水平均与EMT分期呈正相关(r=0.952、0.726、0.884、0.704,均P<0.001)。结论EMT患者入院时血清VEGF、CA125、sICAM-1、EMAb水平明显高于健康者,分期越高,以上指标水平均越高,治疗后以上指标水平明显降低,提示临床可将血清VEGF、CA125、sICAM-1、EMAb作为EMT诊断、分期、评估疗效的重要指标。

Objective To investigate the correlation of serum vascular endothelial growth factor(VEGF),carbohydrate antigen 125(CA125),soluble intercellular adhesion molecule-1(sICAM-1)and anti-endometrium antibody(EMAb)levels with endometriosis(EMT).Methods Clinical data of 200 patients with EMT treated in Lishui Hospital of Traditional Chinese Medicine,Zhejiang Province from July 2019 to September 2020 were collected(observation group).Mean while,clinical data of 69 healthy women who underwent physical examination in the hospital were collected(control group).The general data and serum VEGF,CA125,sICAM-1 and EMAb levels were compared between the two groups.The diagnostic efficacy of the above indexes on EMT was analyzed.The levels of above indexes in different stages or before and after treatment were compared,and those correlations with EMT stages were analyzed.Results Serum VEGF,CA125,sICAM-1 and EMAb levels in the observation group on admission were significantly higher than those in the control group[(865±23)ng/L vs(451±41)ng/L,(976±50)kU/L vs(461±40)kU/L,(341±30)μg/L vs(203±20)μg/L,(0.39±0.05)ng/L vs(0.22±0.01)ng/L](all P<0.001).The sensitivity and the area under curve of combined diagnosis of serum VEGF,CA125,sICAM-1 and EMAb in EMT were significantly higher/greater than those alone(all P<0.05).Serum VEGF,CA125,sICAM-1 and EMAb levels in patients with EMT stageⅠ-Ⅱon admission were significantly lower than those in patients with EMT stagesⅢ-Ⅳ(all P<0.001).After treatment,serum VEGF,CA125,sICAM-1 and EMAb levels in patients with EMT were significantly lower than those on admission(all P<0.001).Serum VEGF,CA125,sICAM-1 and EMAb levels were positively correlated with EMT stage(r=0.952,0.726,0.884,0.704;all P<0.001).Conclusions Patients with EMT have significantly higher levels of serum VEGF,CA125,sICAM-1 and EMAb than healthy people on admission.After treatment,the above indexes significantly reduce.The higher the stage,the higher the above indexes,it is suggested that serum VEGF,CA125,sICAM-1 and EMAb can be used as important indexes for diagnosis,stage,and curative effect evaluation of EMT.