Rncat先天性白内障小鼠模型培育及初步应用

Construction and Preliminary Application of a Rncat Congenital Cataract Mouse Model

先天性白内障是一种严重的致盲性眼病,是导致儿童失明的主要原因。新疆维吾尔自治区疾病预防控制中心成功培育了先天性白内障小鼠模型,并对该模型小鼠(命名为Rncat小鼠)的生物学特性、行为学特性、基因序列及突变体蛋白开展系列研究且取得一定成果,该白内障模型可能为白内障药物筛选及研发发挥重要作用。本文对该Rncat先天性白内障小鼠模型的生物学特性、行为学、基因学和突变体蛋白研究进展进行综述。

Congenital cataract is the main cause of blindness in children.The Center for Disease Control and Prevention of Xinjiang Uygur Autonomous Region successfully constructed mouse models of congenital cataracts.The biological characteristics,behavioral characteristics,gene sequences,and mutant proteins of the model mice were studied,yielding some notable achievements.These novel cataract mouse models may serve as reliable animal models for drug screening and cataract prevention.This paper reviews the research progress on the biological characteristics,behavior,genetics,and mutant proteins of the Rncat congenital cataract mouse model.