2019冠状病毒病相关血栓形成的研究进展

Research progress of COVID-19-associated thrombosis

新型冠状病毒肺炎(2019冠状病毒病,coronavirus disease 2019,COVID-19)是由新型冠状病毒(严重急性呼吸综合征冠状病毒2,severe acute respiratory syndrome coronavirus 2,SARS-Co V-2;简称新冠病毒)引起的一种呼吸系统传染病,是目前人类面临的最大的公共卫生问题。

Coronavirus disease 2019(COVID-19)is a respiratory infectious disease caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Clinical data have indicated that COVID-19 is associated with a significant risk of thrombotic complications ranging from microvascular thrombosis,venous thrombosis,and arterial thrombosis.The evidence to date supports that the thrombotic complications are caused by immunothrombosis,which culminates in the initiation of innate immune responses due to SARS-CoV-2 invading endothelial cells,and subsequent endothelial inflammation,complement activation,thrombin generation,and platelet and leukocyte recruitment.Several antithrombotic drugs have been explored as potential therapies to prevent COVID-19,and the antithrombotic therapy will hopefully improve outcomes for patients with COVID-19-associated thrombosis.