原发性干燥综合征患者生活质量现状调查

Survey of Quality of Life in Patients With Primary Sjogren's Syndrome

目的研究原发性干燥综合征(pSS)患者生活质量现状及影响因素。方法收集2021年1—2月厦门大学附属第一医院风湿免疫科随访的112例pSS患者基本信息、健康状况调查问卷(SF-36)评分、自我报告指数(ESSPRI)等资料,分析生活质量现状与ESSPRI、年龄、教育程度等相关性及影响因素。结果在生活质量评分中,年龄只与生理机能有相关性(P<0.01),眼干病史长短与一般健康状况(P<0.01)及总的生理领域评分(P<0.05)有相关性,口干病史长短与一般健康情况、躯体疼痛、总的生理及心理健康领域有相关性(P<0.05),受教育程度与生理机能(P<0.01)有相关性,但均和生命质量其他维度无相关性(P>0.05)。ESSPRI与SF-368个维度、2个领域的Spearman相关性分析结果提示两两间均有相关性(P<0.01),ESSPRI评分越高,生活质量越差。过去两周疼痛程度(β=-0.432,P<0.01)、疲劳程度(β=-0.275,P<0.01)可以显著负向影响生理健康,过去两周疲劳程度可以显著负向影响心理健康(β=-0.577,P<0.01)。结论积极关注及改善患者的疼痛、疲劳、眼干口干情况可以有效提高pSS患者生活质量。

Objective To investigate the quality of life in the patients with primary Sjogren's syndrome(pSS)and its influencing factors.Methods A total of 112 patients with pSS were followed up in the Department of Rheumatology and Immunology of the First Affiliated Hospital of Xiamen University between January and February 2021.Their basic information,the medical outcomes study 36-item short form health survey(SF-36)and EULAR SS patient reported index(ESSPRI)were collected.Results In the quality of life score,age was only related to physiological function(P<0.01),and the course of dry eye symptom was correlated with general health(P<0.01)and physical condition scores(PCS)(P<0.05),while the course of dry mounth symptom had correlation with general health,bodily pain,PCS and mental condition scores(MCS)(P<0.05),and the levels of education was related to physical functioning(P<0.01),but all have no correlations with other dimensions of quality of life(P>0.05).There were obvious correlations of ESSPRI with eight dimensions and two areas of SF-36(P<0.01).Higher ESSPRI score was significantly correlated with worse quality of life.Pain degree(β=-0.432,P<0.01)and the degree of fatigue(β=-0.275,P<0.01)in the past two weeks could significantly negatively affect physical health.The degree of fatigue in the past two weeks can significantly negatively correlated mental health(β=-0.577,P<0.01).Conclusion Paying more attentions to the alleviation of degree of pain,fatigue and dryness could effectively improve the quality of life of patients with pSS.