血小板与淋巴细胞比值对急性肺栓塞患者死亡风险的预测价值

Predictive value of platelet-lymphocyte ratio in patients with acute pulmonary embolism

目的探讨血小板与淋巴细胞比值(PLR)对急性肺栓塞(APE)患者死亡风险的预测价值。方法选取我院2014年1月10日~2019年11月2日因APE住院患者137例,根据PLR水平分为PLR>176组及PLR<176组,收集两组患者的临床资料,并对患者进行1个月的随访,记录两组患者主要心血管不良事件(MACE)发生情况,并进行危险因素分析。结果PLR>176组的患者血尿素氮(BUN)水平明显高于PLR<176组的患者(P<0.05)。单因素Logistic回归结果显示,PLR(OR=1.003,P=0.024,95%可信区间为1.000~1.006)、BUN(OR=1.089,P=0.017,95%可信区间为1.015~1.169)是发生MACE危险因素。多因素Logistic回归结果显示,PLR(OR=1.003,P=0.037,95%可信区间为1.000~1.006)、BUN(OR=1.103,P=0.011,95%可信区间为1.023~1.190)是发生MACE危险因素。结论PLR是APE患者不良预后独立风险因素,密切监测PLR水平对判断APE病情进展及预后有重要意义。

Objective To investigate the predictive value of platelet-to-lymphocyte ratio(PLR)in mortality risk of patients with acute pulmonary embolism(APE).Methods A total of 137 inpatients with APE from January 10,2014 to November 2,2019 in Ganzhou People's Hospital were selected and divided into PLR>176 groups and PLR<176 according to PLR level.Basic clinical data were collected and the differences were analyzed.The patients were followed up for one month.The major adverse cardiovascular events(MACE)in two groups were recorded and the risk factors were analyzed.Results PLR>176 group showed the following characters compared with PLR<176 group:the Blood urea nitroge level was high,the difference was significant(P<0.05).Univariate Logistic regression analysis indicated that PLR[odds ration(OR)1.003,95%CI(confidence interval)1.000-1.006,P=0.024],Blood urea nitroge level[OR 1.089,95%CI 1.015-1.169,P=0.017]were the independent predictors of MACE.Multivariate Logistic regression indicated that PLR[odds ration(OR)1.003,95%CI(confidence interval)1.000-1.006,P=0.037],Blood urea nitroge level[OR 1.103,95%CI 1.023-1.190,P=0.011]were the independent predictors of MACE.Conclusion PLR was an independent risk factor for poor prognosis in patients with APE.Close monitoring of PLR level is important for judging the progression and prognosis of APE.