局灶性皮质发育不良相关癫痫的诊疗进展

Advances in the diagnosis and treatment of epilepsy associated with focal cortical dysplasia

局灶性皮质发育不良(FCD)是临床中常见的局灶性癫痫的病理类型之一,多数FCD患者在癫痫起病后即表现出耐药性,成为难治性癫痫。2011年国际抗癫痫联盟提出了新的FCD病理分型后,让大家对FCD有了更进一步的认识。近几年随着医学检测技术、病理研究及神经影像技术的发展,针对不同病理亚型的研究使得临床医生对FCD致病机制及治疗措施的决策有了新的理解。该文综合近年相关文献,对FCD不同亚型临床特点、治疗方法及相关预后作一综述,以期为临床决策提供帮助。

Focal cortical dysplasia(FCD)is one of the common pathological types of focal epilepsy in clinical practice,and most of FCD patients show drug resistance immediately after the onset of epilepsy and become intractable epilepsy.The new pathological classification of FCD proposed by the International League against Epilepsy in 2011 helps us gain a better understanding of FCD.With the development of medical detection technology,pathological research,and neuroimaging technology in recent years,the research on different pathological subtypes has helped clinicians to have a new understanding of the pathogenesis of FCD and the decision of treatment measures.With reference to related articles in recent years,this article reviews the clinical features,treatment methods,and prognosis of different subtypes of FCD,in order to provide help for clinical decision-making.